Sergio Cruz-León

We are excited to announce the publication of high confidence 3D template matching for #cryoET @HummerLab @Beck_Laboratory @jpkreysing @geissler_katha @s_l_schaefer @pc_hoffmann @MPIbp @cziscience Paper's link: nature.com/articles/s4146… See it in action in our short video!

❄️🌈 Now out in Nature Methods: nature.com/articles/s4159… Couldn’t be happier!

Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ @jpkreysing, Johannes Betz,Turoňová lab, @MarinaLusic, Hummer lab, @Beck_Laboratory, @MPIbp 🔗 Preprint here: doi.org/10.1101/2025.0…

Fresh out of the press! ✨Check out our new paper on the violent entry of the HIV capsid into the nuclear pore — watch it crack that gate! 🤯 💥 Incredible work from @Beck_Laboratory and @HummerLab 🤩 More here: biophys.mpg.de/2842024/hivcap… 🔗

Difference between diffusion and flow? If you drip paint into a river it locally dissolves by diffusion. It goes downstream driven by flow. We quantify flow through #nuclearpores in response to rapid nuclear size changes. @MPIbp #TEAMTOMO @MolecularCell cell.com/molecular-cell…

cryoTIGER: Deep-Learning Based Tilt Interpolation Generator for Enhanced Reconstruction in Cryo Electron Tomography biorxiv.org/content/10.110…

Molecular dynamics simulations in mixed reality! With @labriataphd and @lucien_krapp we’re scaling our multi-user WebXR platform to enable immersive molecular simulations, fully based on web technologies. Stay tuned, lots of cool stuff coming soon! @threejs #WebXR #Quest3

Excited to share our new publication in the Journal of Physical Chemistry Letters. In this work we have analyzed the effect of crowding on protein and hydration dynamics in biocondensates. Details in the following link. doi.org/10.1021/acs.jp… #JPCL #LLPS #Condensate #Dynamics

Thanks to @WAutophagy for giving me the opportunity to present our work looking at the organisation of the selective autophagy cargo Ape1 by in situ cryo-electron tomography ❄️🔬at #WIA2024meeting. What a great symposium!

🚨Checkout our new publication from @IBC2_GU @goetheuni to learn how IDRs amplify membrane remodeling during ER-phagy. Dive into our findings here: pnas.org/doi/10.1073/pn… @EnableFrankfurt @sfb1177 🔬 @SCALE_Uni_FFM @HummerLab @DikicLab

Ready for the final day of the BPS meeting on 'Emerging Theoretical Approaches to Complement Single-Particle Cryo-EM' in Trieste! 🔬 We had outstanding speakers, great science, and friendly atmosphere. Thanks to @BiophysicalSoc @cecamEvents, @palermo_lab @RommieAmaro @LanderLab!

** Job Alert**: Are you looking for a postdoc in computational physics (including statistical mechanics, biophysics, fluid mechanics, quantum physics, and molecular dynamics), apply to CCM at the Flatiron Institute apply.interfolio.com/155357

My babies are on the cover of The EMBO Journal! I couldn't be happier and prouder of this journey alongside with my colleagues and collaborators, which has led to this amazing publication. Enjoy it once again!😌 @MishaKudryashev @MPIbp

Did you know that nuclear pore complexes can turn up outside the nuclear envelope? Studying these, @JennySachweh, Bernhard Hampoelz and others uncover that the surrounding cellular milieu determines NPC composition via the nuclear transport system itself. #teamtomo #NPC A 🧵

Check out JP’s virtual lift-out experiment that made it on the cover of Nature Methods!

Check out our article on the tetrameric forms of the serotonin-gated 5-HT3A receptor ion channel! This work, combining SPA cryo-EM, cryo-ET and MD simulation, was made possible by the collaboration between @MishaKudryashev, Prof. Vogel and Dr. Yuan labs. embopress.org/doi/full/10.10…

You are still in time to register and submit a poster abstract for the "2nd BioExcel Conference on Advances in Biomolecular Simulations" Don't miss this fantastic event with top speakers 🔝 Registration ➡️ bit.ly/3TBqidQ

📣 WE ARE HIRING (TT assist. or assoc. prof) Come be my colleague at the University of Copenhagen 🇩🇰! Copenhagen is a great city to live in 🚲🌤️ 👪 and you will have lots of great colleagues 🧑‍🔬🧑‍💼 working on diverse topics🧪🧫🧶🍝🧬🖥️ Deadline Sept 22: employment.ku.dk/faculty/?show=…

How could CO₂ fixation occur in anaerobic and ancient life? Our new preprint sheds light on catalytic mechanism of the key enzyme CODH/ACS in the Wood-Ljungdahl pathway. Watch the summary movie to see how CO₂ is transformed into acetyl-CoA. Read more: t.ly/u3Ir0

Long-term live-cell super-res microscopy! 👉🏻our new preprint (tinyurl.com/bdjjju45) reports >6h STED imaging of ER dynamics in live cells with seconds time resolution. It combines low-light imaging and NN-assisted denoising🔬

Happy to see our study on the structure of 46-kDa Streptococcus pneumoniae NOX out in @NatureSMB! Congratulations to the authors @PABLOSANSEGUND3 and @vicsnorr 🥳 Check it out here (open-access) 👉 t.ly/T0oej