Kresten Lindorff-Larsen
@LindorffLarsen
Protein and coffee lover, father of two, professor of biophysics and sudo scientist at the #LinderstrømLang Centre for Protein Science 🇩🇰
AF2χ: Predicting protein side-chain rotamer distributions with AlphaFold2
Two recent preprints from a great collaboration with Rasmus Hartmann-Petersen's lab on mapping degrons in (1) 5,000 human cytosolic proteins and (2) 1,600 human transcription factors 1: doi.org/10.1101/2025.0… 2: doi.org/10.1101/2025.0…
You can still sign up for this anniversary symposium. And if you’re a former sbinner (MSc, PhD, PD) and haven’t received an invitation email to the celebration party please drop an email to Birthe, Kaare, Pétur, Elo or myself. We look forward to seeing you
The Structural Biology and NMR Laboratory—or SBiNLab as we call it—is turning 25 🎉🧲🇩🇰 We're celebrating with a symposium on Aug. 23 that is free and open to all Great speakers incl. Ad Bax, Frauke Gräter, Harald Schwalbe, Sarah Shammas, Mikael Akke & alumni! Join us
AlphaFold2 was built to predict a single structure, but it seems to be hiding an ensemble 😅 AF2χ mines internal χ-angle signals to predict side-chain flexibility with MD-level accuracy IMHO, they really bury the lede here, finding (in the supplemental figures) that AF2χ is up…
📢 Registration Now Open: ISBUC Annual Meeting 2025! Join us on Friday Oct 24th for the ISBUC Annual Meeting, a full-day celebration of cutting-edge research in integrative structural biology! 🔬 Dive into the latest developments and interdisciplinary breakthroughs with an…
Supervised learning of protein variant effects across large-scale mutagenesis datasets
Supervised learning of protein variant effects across large-scale mutagenesis datasets biorxiv.org/content/10.110… #biorxiv_biophys
Deadline for registration to our Benzon Symposium on Protein structure prediction and design in biology and pharmacology is on Monday (March 31st, noon DK-time) Submit you abstracts via: benzon-foundation.dk/benzon-symposi…
⏰ Two weeks left to register for our Benzon Symposium on protein structure prediction and design 🧶🍝🧬🖥️ Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and will feature an amazing list of speakers 👨🔬👩🔬👩💻👨💻
Phase Space Invaders' episode 27 is now online, featuring Kresten @LindorffLarsen! Listen to it on Spotify or other platforms: buzzsprout.com/2313153 In our conversation, Kresten gives great concrete examples of experimental developments being translated into breakthroughs in…
Very happy to share our next extension to the CALVADOS protein force field: If you want to explore the changes in global dimensions of a disordered protein upon phosphorylation: give it a read and a try! Big thank you to @GiulioTesei , @LindorffLarsen and Gustav Hedemark
CALVADOS now has parameters for phosphorylated amino acids
Gemma Solomon and I are looking for a postdoc to work across the two groups on modelling biological systems with a view to applications for quantum computing More details about the project including how to apply in the link below. Deadline April 9 2025 candidate.hr-manager.net/ApplicationIni…