Takashi Fukaya
@FukayaLab
Institute for Quantitative Biosciences, UTokyo. We study the mechanism of transcriptional regulation in the Drosophila embryo.
How do distal enhancers control transcription dynamics in living cells? Check out our latest work published in @MolecularCell!! We show that the dynamic assembly and disassembly of TF clusters at enhancers are a major source of transcriptional bursting. cell.com/molecular-cell…
nature.com/articles/s4158… Wow! 1,700 transgenic mice for the most comprehensive enhancer characterization ever. Leo and Axel never cease to amaze!
🚨Our latest work on selfish centromeres published at @CurrentBiology 🐭🧬We found that the spindle checkpoint contributes to non-Mendelian segregation! Huge congrats to my lab manager, Zaak Walton, who led the project🎉 Free link authors.elsevier.com/a/1lQzN3QW8SA3…
Our preprint describing the Range Extender element, which is required and sufficient for long-range enhancer activation at the Shh locus, is out in @Nature. nature.com/articles/s4158…
How do enhancers work over distances that sometimes exceed megabases? Excited to share our work led by @gracecbower where we uncover a unique sequence signature globally associated with long-range enhancer-promoter interactions in developing limb buds: biorxiv.org/content/10.110… 1/
New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? biorxiv.org/content/10.110…
Design of intrinsically disordered region binding proteins | Science science.org/doi/10.1126/sc…
Architectural RNAs: blueprints for functional membraneless organelle assembly dlvr.it/TLKTCW
Excited to share our latest work! We found transcription factor SPT6 and phosphorylated Pol II CTD help recruit U1 snRNP to elongating Pol II, allowing efficient co-transcriptional splicing. Glad to be featured in the Editors’ Highlights! nature.com/articles/s4146… #splicing
Our new work @biorxivpreprint 🔗biorxiv.org/cgi/content/sh… BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via bromodomain-mediated crosslinking: physical control of #chromatin by #LLPS transcription condensates. @semeigazin @katsu_s_minami @MasaAShimazoe
The ASIA RNA Club (Japan, Korea, China, Taiwan, Singapore, Australia), which used to be held online, is pleased to announce its 1st in-person meeting! Please join us in Seoul, Korea (Nov. 3 to 5), with Dr. Narry Kim of SNU as the main organizer! #ASIA_RNA asiarnaclub.org
Japan is the only country in the world that legally requires married couples to share the same family name go.nature.com/4kmulF1
Our work, co-led by @AlfredoFlorez and @NicholasLue, is finally out in @NatureSMB. Shout out to coauthors P.Grob, B. Kaeser, J.Fang, and Susanne Kassube for their contributions, and thanks to the reviewers for their suggestions that led to the final work. nature.com/articles/s4159…
"Here we present the first direct evidence that H3K4me3 is not a cause but a consequence of transcriptional activation, functioning as a downstream epigenetic response" biorxiv.org/content/10.110…
Delighted to share a new review paper from the lab. We discussed recent key findings in enhancer biology. Thanks Dan Larson and @tinekelenstra for this opportunity!! sciencedirect.com/science/articl…
Our new paper “Representation of sex-specific social memory in ventral CA1 neurons” is out today!! @ScienceMagazine Congratulations to @hi_ni_hikaru & @taoizm🎉 science.org/doi/10.1126/sc…
Excited to share that our paper is now published! Together with Aki Watarai, we have discovered how the mouse brain integrates multiple social features, such as sex, into cohesive social memories. science.org/doi/10.1126/sc…
Online Now: Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function dlvr.it/TLjNk8
New from the Rouhanifard Lab! What if we could sort single cells based on whether a specific gene was actively being transcribed—and then ask what drives that burst? Introducing: NuclampFISH
A live-cell biosensor of in vivo receptor tyrosine kinase activity reveals feedback regulation of a developmental gradient dlvr.it/TLfp6Q
Our new RNA tool is just out ! Great work of Itsuki Abe & Hirohisa Ohno☺️This split RNA switch boosts the simultaneous detection of biomolecules (miRNAs or proteins) and improves the precision of cell-type–specific protein expression & genome editing! doi.org/10.1038/s41467…
There is still time until July 18 to submit an abstract to CSH Asia conference “Nuclear Architecture and Function”. Check out the fantastic lineup of speakers! csh-asia.org/?content/2743