Evgeny Kvon

Happy to share our recent work, led by @ewholling in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. @UCIBioSci @UCIrvine biorxiv.org/content/10.110…

We're hiring! Our group @arcinstitute and @Stanford has postdoc openings in 1) discovering and developing next-generation therapeutic delivery vehicles, and 2) tracking cellular dynamics. Email me if you're interested! hornslab.org

rdcu.be/ewyC7 , rdcu.be/ewyDR we were wondering if Lhx2/Ldb1 solid condensates could be general- so cool to see at the same issue that range extender elements have Lhx2/Lhx9 motifs!

Delighted to share a new review paper from the lab. We discussed recent key findings in enhancer biology. Thanks Dan Larson and @tinekelenstra for this opportunity!! sciencedirect.com/science/articl…

How do non-coding variants in enhancers cause human disease? Here, in my main PhD work with @evgenykvon, we uncover a surprising mechanism, with generalizable implications for human genomics. tinyurl.com/89tdkevu n/

The attacks on foreign researchers at Harvard and elsewhere are appalling. Scientists from other countries have enriched my education, training and research at every single stage of my career, and have become my closest and most cherished colleagues and friends. If there is a…

rdcu.be/el185 Thrilled to see this out! Solid phase transitions hold interchromosomal enhancer hubs together for life. The amazing @JoanPulupa and Natalie McArthur combined forces to discover a new type of condensate that remains intact for days in olfactory neurons

Exciting news from our latest collaboration between Prof. Jussi Taipale's Lab Group (taipalelabs.org) and Prof. Yimeng Yin's Lab: our comprehensive screen of 58,000+ transcription factor pairs is now published in @Nature: nature.com/articles/s4158… 1/10

Very excited to share our latest work in @NatureComms where we identify two limb mesenchymal progenitor populations involved in congenital and evolutionary digit variation. Congratulations to all authors involved, it’s been such a good team work. nature.com/articles/s4146…

The first story of my PhD out now in final published form, including new untested variants (see below)!

Our preprint is out nature.com/articles/s4146… In a new set of experiments, we screened a panel of rare and common variants from patients with Autism and identified variants in enhancers of OTX2 & Mir9-2 that reproducibly alter their activity in vivo! Huge congrats to @ewholling

Read this #preprint on @researchsquare: DNA sequence-induced solid phase transitions as a solution to the genome folding paradox researchsquare.com/article/rs-544… Not how I had imagined Richard Axel's olfactosome, but so proud of @JoanPulupa , Natalie G. McArthur, Olga and the team!

Beyond happy to share the most exciting findings of my PhD research in the @stark_lab. 🤩 tinyurl.com/k6rbxjwn Our genome-wide silencer screen revealed that silencers are different from your typical regulatory DNA element. Find out more below 👇 (1/9)

Online Now: A genome-wide screen identifies silencers with distinct chromatin properties and mechanisms of repression dlvr.it/TGHjyy

Analyzing whole genome DNA methylation data? Our new method MethyLasso is out in NAR! It can help you identify regions with low or partial methylation (LMR, UMR, DMV, PMD, PMD) or differentially methylated regions (DMR) and was benchmarked against others doi.org/10.1093/nar/gk…