Iain Cheeseman
@iaincheeseman
Whitehead Institute and Department of Biology, MIT. Lover of cell biology and cell division. Aspiring to do good science and to do good.
With the new academic year starting, and many people beginning fresh as graduate students, post-docs, or junior faculty, I have been thinking a lot about the core philosophies that govern my own perspectives on science. So I thought I would share. Welcome to The Tao of Cheese
New preprint w/ surprising insights into proteasomes + mitosis. Océane Marescal found strikingly different cellular phenotypes for proteasome knockouts. 19S lid depletion results in ubiquitin-INDEPENDENT degradation of KIF11 motor + monopolar spindles. biorxiv.org/content/10.110…
Princeton's new Bioengineering Institute @omenndarlingbio is hiring! New building opening this Fall, & Princeton is awesome place to live & do amazing research at intersection of engineering & life sciences. **Please spread the word*** bioengineering.princeton.edu/join/open.
Optical pooled screening is revolutionizing functional genomics by linking genetic perturbations to complex cellular phenotypes at unprecedented scale. But analyzing these massive datasets has been a major bottleneck - researchers face fragmented tools, multiple format…
Optical Pooled Screening has transformed large-scale cell biology, but lacks robust end-to-end computational strategies to process these Tb-sized datasets. New from Di Bernardo et al (@mat10_d): Brieflow. A game changer for OPS + new biological insights biorxiv.org/content/10.110…
Optical Pooled Screening has transformed large-scale cell biology, but lacks robust end-to-end computational strategies to process these Tb-sized datasets. New from Di Bernardo et al (@mat10_d): Brieflow. A game changer for OPS + new biological insights biorxiv.org/content/10.110…
New preprint drop! Check out work from Jimmy Ly et al for how protein isoforms generated by alternate translation initiation create dual localization, contribute to mitochondrial function, and are mutated in disease. Tweet-tutorial thread below. biorxiv.org/content/10.110…
New preprint countdown! Mitochondria are cells within our cells. They need the same core activities - replication, transcription, translation. How do cells enable these diverse activities in both compartments? We uncover an unexpected strategy with ancient origins. Stay tuned!
Researchers in the Cheeseman lab have identified an important molecular switch that induces a distinct pattern of protein variant production during mitosis. #ResearchHighlights
New preprint! Eric Smith + Jimmy Ly reveal a beautiful example of repurposing of a molecular machine. RNase P + RNase MRP share 9 subunits and yet are functionally very different. We find key new subunits that act as specificity factors to distinguish MRP. biorxiv.org/content/10.110…
We are excited to kick off the new year with a new publication from the lab!
Acevedo-Sánchez et al. @lamasonlab @MITBiology characterize a novel interkingdom contact site between the ER and a cytosolic bacterial pathogen. They report that these bacteria–ER contacts (BERCs) require the tethering proteins VAPA and VAPB. hubs.la/Q031sGkq0 #Microbiology
Excited to share that the Nguyen lab website is live Nguyenlab.org ! Check out what we are working on and if you are at ASCB next week come say hello! We will be presenting a poster Monday at board B277