Tianpeng Zhang
@zhtianp2
Assistant Professor at RO Dep of UVA SOM; Interested in telomere/ genome integrity and more
Happy to share our updated opinion on the physiological roles of BRCA1 in this new review: authors.elsevier.com/a/1lDKu3QxxSyl…
My lab is recruiting! We study respiratory immunology, chronic lung diseases and aging. Come join us @UVAimmunology at the beautiful UVA campus and Charlottesville. Please help spread the words.
Online Now: TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling dlvr.it/TLjbyj
Why does cytarabine hit the brain so hard? 🧠It causes DSBs, especially in Purkinje cells! Meanwhile, Gemcitabine plays much nicer! Check out our paper in Nature today! Huge thanks to my mentor André Nussenzweig @nussenza and all my amazing colleagues! nature.com/articles/s4158…
WE ARE HIRING: Postdoc Positions! Join us at UPenn in vibrant Philly, cutting-edge science, great city, amazing team. Please share and let's get in touch!
Endogenous tagging of BLM and PICH reveal their dynamic localization and functions throughout the cell cycle. New preprint: Mitotic BLM functions are required to maintain genomic stability biorxiv.org/content/10.110…
In our latest paper, we uncover condensin II as a novel BLM interactor critical for genome stability in S phase. Condensin II contributes to BLM localization at active forks and undergoes a transient structural change in S phase.nature.com/articles/s4200…
Wondering what is a nucleoporin doing at repair sites? Check it out in our most recent paper in Molecular Cell! dlvr.it/TLBMbH
🧬New from crystal structures from our lab in EMBO J! We reveal how the FANCM enzyme, an emerging therapeutic target it cancer, has evolved to specifically recognise branched DNA and activate the Fanconi anaemia pathway of DNA repair. doi.org/10.1038/s44318… 🧵👇
We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested, closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationIni…
Excited to share our publication out in Science today! We define a role for the CST complex in DSB repair pathway choice. This study was conducted in close collaboration with Patrick Sung’s lab. Congratulations to Michelle Swift and all other authors! science.org/doi/10.1126/sc…
In this study, Seppa et al. dissect the mechanisms by which DNA nucleases resect single-strand DNA gaps and regulate repair kinetics, with critical implications for BRCA1-deficiency and PARP inhibitor sensitivity. #OpenAccess Learn more here: ➡️ tinyurl.com/gd352421
Delighted to share that the results of my main postdoc project are now published in @Nature 🔗 doi.org/10.1038/s41586…
Sharing our latest work @UZH_en tracking DNA damage inheritance by Live+QIBC nature.com/articles/s4158…. Huge congrats to @APanagopoulos_, M. Stout and all co-authors for this tour de force! Beautifully summarized by @S_J_Aitken and E. Reilly @NatureNV nature.com/articles/d4158….
Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come nature.com/articles/s4158…
We designed “Rainbow Nucleus” to reveal the secret relationships among five major nuclear membrane-less organelles using live-cell imaging. A lot is unknown: what mediates these interactions? What are the functions? biorxiv.org/content/10.110…
Our review epub @CSHLPress. Great ride led by Luis Batista @WashUHematology & by @CeiFccc @FoxChaseCancer contributing to an understanding of telomerase RNP - the immortality enzyme hijacked by 85% cancers and the untapped "fountain of youth" for aging diseases.…
Please see our discovery of first-in-class BRISC deubiquitylating enzyme inhibitors rdcu.be/edRwF. A great journey with Elton Zeqiraj, Francesca Chandler, Joe Salvino. High-throughput screens, cryo-EM structure and ontarget activity to reduce inflammatory signals.
🧬⛓️ Our latest preprint examines the fate of collapsed forks in vertebrates 🐸 and our colleagues in @heathmurraylab asked similar questions in bacteria 🦠 Together our studies indicate that the response to fork collapse is shaped by evolution (see🧵) biorxiv.org/content/10.110……
💫NEW: Hervé, Scelfo et al. show that #chromosome missegregation induces #mTORC2 - & ATR-mediated p53 activation via a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochromatin content and increased nuclear membrane tension. nature.com/articles/s4155…