Jia-Cheng Liu

Happy to share our updated opinion on the physiological roles of BRCA1 in this new review: authors.elsevier.com/a/1lDKu3QxxSyl…

Cytarabine has been the mainstay for AML treatment. This chemotherapy can lead to problems with movement and balance. Here we explain this neurotoxic side effect: nature.com/articles/s4158…. Work led by Jia-Cheng Liu, Donpgeng Wang, Elsa Callen and many terrific collaborators!

Why does cytarabine hit the brain so hard? 🧠It causes DSBs, especially in Purkinje cells! Meanwhile, Gemcitabine plays much nicer! Check out our paper in Nature today! Huge thanks to my mentor André Nussenzweig @nussenza and all my amazing colleagues! nature.com/articles/s4158…

Happening Now in the Skyline Ballroom: Andre Nussenzweig is presenting his lecture, "Maintaining genome stability." asbmb.org/asbmb-today/pe… #ASBMB25

Congratulations to Andre Nussenzweig (@nussenza) at @NCIResearchCtr on winning the Bert and Natalie Vallee Award in Biomedical Science! His research examines genome stability as well as DNA repair pathways and their roles in cancer prevention. asbmb.org/asbmb-today/pe… #ASBMB2025

A high-resolution view of how replication-coupled DNA breaks are generated, processed and repaired. Congrats to @pavani_raphael, @TripathiVeenu, and many terrific collaborators including @FrogWalterLab, @CejkaLab, @weiwsmiling. See science.org/doi/epdf/10.11…

With their help, we found formulations of engineered nanoparticles that can efficiently deliver Cas9 into (iPSC-derived) postmitotic human neurons. And cut open their DNA. @JiaChen98369353 from @nussenza lab took pictures of these Cas9-induced breaks in our neurons’ DNA.