Chowdhury Lab

📢 For all HaloTag lovers💙💚💛❤️💜🩶 we are excited to share that our work, in which we developed a new biotin-HaloTag ligand, is now published in @JCellBiol! Full link here: rupress.org/jcb/article-ab…

Excited to share our publication out in Science today! We define a role for the CST complex in DSB repair pathway choice. This study was conducted in close collaboration with Patrick Sung’s lab. Congratulations to Michelle Swift and all other authors! science.org/doi/10.1126/sc…

Thank you to @ChowdhuryLab (@Harvardmed, @DanaFarber) for joining us for a fantastic #WednedsayLectureSeries on "#DNA repair mechanisms in the context of cell cycle with implication in #cancer." 🧬 Hosted by the Si Lab.

📣 Excited to share our latest review on 53BP1’s function in replication stress, its role in fork protection, and the significance of 53BP1 nuclear bodies in this context! sciencedirect.com/science/articl…

🚨 TENURE-TRACK Faculty Opportunity The Genome Integrity Program @UMassChan umassmed.edu/genomeintegrit… Join us exploring DNA replication/repair with Core services supporting your cutting-edge research. 🔗 Learn more: academicjobsonline.org/ajo/jobs/28037 #Genomics #FacultyJobs #Research #Science

Out in @Nature today! We report that a CDK5-cyclin B1 complex maintains proper cell division. We discovered that CDK5, a long regarded non-cell cycle CDK functioning only in neurons, yet overexpressed in many cancers, does regulate mitosis!  Link: nature.com/articles/s4158…

Happy to announce our new publication in @NatureComms, spearheaded by super-talented project leader @ReuterLM . We identified that helicase loading is a self-limiting reaction supporting equal distribution of the replicative helicase across the genome. rdcu.be/dRTAZ

Very grateful that Dana-Farber’s Center for BRCA and Related Genes in collaboration with the @UTHealthSA has been awarded a $3M program project grant from the @theNCI. Honored to lead the research under the new grant with Dr. Panagiotis (Panos) Konstantinopoulos.

📢SAVE THE DATE: 7-10 July 2025 @AgnelSfeir , @KarleneCimprich & @ChowdhuryLab are chairing the #BGFP25 which is taking place in wonderful Lisbon, Portugal next July.☀️ Registration is now OPEN, for more info and details on how to register, follow the 🔗: bit.ly/3AnsVZF

Happy to share a publication from the lab demonstrating that 53BP1 loss is a positive predictive biomarker for immune checkpoint blockade efficacy, with important implications for the treatment of PARPi-resistant ovarian and pancreatic cancers! nature.com/articles/s4146…

Happy to share a new study from our multitalented fellow Eva Tsaousidou ⁦@gshlab_ulkerctr⁩ in collaboration with ⁦@ChowdhuryLab⁩. Here, we show that tolerable activation of p53 protects against cancer at the cost of metabolic health 👏🧿. cell.com/cell-reports/f…