Genes & Development

NEW ISSUE ALERT!!! Check out the new Outlook, Review and Research Papers online now at Genes & Development. Click on the link for more: ➡️ genesdev.cshlp.org/content/current

In this Outlook, Huang et al. highlight the heterogeneity of pineoblastoma's pathogenic mechanisms with implications for therapeutic interventions. #OpenAccess Read the Outlook: ➡️ tinyurl.com/gd352932

In this study, Fraire et al. elucidate the impact of the loss of microRNA processing on pineoblastoma formation, illustrating parallel mechanisms that can be leveraged into combinatorial anti-tumor therapies. Learn more here: ➡️tinyurl.com/gd352485

In this study, Mouginot et al. describe the formation and function of meta-domains−megabase-range chromatin contacts−that underpin the complexity and specificity of neuron-specific genome architecture and gene expression. Learn more here: ➡️ tinyurl.com/gd352646

In this Review, Solé-Ferran and Losada discuss the mechanisms by which the cohesin complex facilitates chromatin looping and sister chromatid cohesion and their implications for embryonic development and cohesinopathies. #OpenAccess Learn more here: ➡️ tinyurl.com/gd352671

In this study, Tran et al. show that Notch signaling controls the switch from neuronal fates to oligodendrocyte fates—in response to Sonic hedgehog signaling—during late embryogenesis. Learn more here: ➡️ tinyurl.com/gd352555

In this study, Perry et al. report that TEAD performs YAP/TAZ-dependent and -independent functions by switching interacting partners during brain development and neuronal lineage progression. Learn more here: ➡️ tinyurl.com/gd352632

In this study, Mimoso et al. show that Restrictor serves as a transcriptional safeguard that suppresses the spurious transcription of non-coding RNAs, while preserving mRNA transcription. Learn more here: ➡️ tinyurl.com/gd352654

In this Outlook, Rodeheffer discusses this study and highlights the functional importance of the ETS family of transcription factors in lineage decisions and cell function. #OpenAccess Read the Outlook: ➡️ tinyurl.com/gd352966

In this study, Xue et al. identify a distal enhancer that interacts with transcription factor ETV4 to control brown adipose thermogenesis, with implications for metabolic diseases like obesity and diabetes. #OpenAccess Learn more here: ➡️ tinyurl.com/gd352748

📽️ G&D Tapes 📽️ G&D author, Noah Helton tells us about their new study in #genesdev, revealing an intriguing link between stress granule formation and the integrated stress response. #OpenAccess @smslmoon Read the full story here: ➡️ tinyurl.com/gd352899

In this study, Helton et al. explore the link between stress-induced gene expression and mRNA condensation into stress granules. #OpenAccess @smslmoon Learn more here: ➡️tinyurl.com/gd352899

G&D’s Editor-In-Chief, Professor Andy Dillin is attending the #GLIA2025 in Marseille. If you’d like to share your work with us or learn about the journal, feel free to drop by or reach out to [email protected] @GenesDev @dillinlab

In this Review, Bodur et al. discuss the intricacies of neural control of leptin signaling and its implications for food intake, body weight, metabolism, and disease. #OpenAccess Learn more here: ➡️ tinyurl.com/gd352550

📽️ G&D Tapes 📽️ G&D authors, @A_Chocarro @CustodiaGJ_Lab @migueljoci99 tell us about their recent study in #genesdev describing the metabolic cross-talk between melanoma and adipose, and the influence of nutrients on metastasis. Learn more here: ➡️ tinyurl.com/gd351985

In this study, Magesh et al. describe the metabolic consequences of breast cancer-associated, net gain aneuploidy on mammary epithelial cells, identifying dependencies to improve chemotherapeutic response. #OpenAccess @game_of_chroms Learn more here: ➡️ tinyurl.com/gd352512

📽️ G&D Tapes 📽️ G&D author Aitana Verdu Schlie tells us about their new work in #GenesDev about CDK4's role during development, with mutations causing microcephaly and growth defects. #OpenAccess Read the full story here: ➡️ tinyurl.com/gd352311

In this study, Dehmer et al. show that the USP11/TCEAL1 complex buffers TFIIS's function in RNAPII backtracking, promoting transcription elongation and oncogenic transcription in neuroblastoma. Learn more here: ➡️ tinyurl.com/gd352166

In this study, Chen et al. describe two distinct mechanisms that control β-catenin levels underlying MEK-mediated proliferation in neuroglial cells, important during NF1-loss or BRAF rearrangement in pediatric gliomas. #openaccess Learn more here: ➡️tinyurl.com/gd352508

G&D Executive Editor, Dr. Eric Sawey is attending @KeystoneSymp #KSNeuroImmune25 in Whistler! If you’re in town, stop by to discuss your work or reach out to @Eric_GenesDev or [email protected] to set up a good time to chat.