🔬Andrew Deans🇦🇺
@GenomeStability
Head of Genome Stability Unit at SVI, Melbourne. All things DNA damage response: Fanconi Anaemia, Bloom Syndrome, Gene editing, R-loops, telomeres, HR & more
Today in @CellCellPress we report the use of prime editing to correct several mutations that cause alternating hemiplegia of childhood (AHC), a rare and devastating neurodevelopmental disorder, in patient-derived cells and in two mouse models. drive.google.com/file/d/1ibC50t… 1/10
Register for the Australian Cell Cycle, DNA Repair & Telomere Meeting in beautiful Melbourne October 19-22, 2025. Plenty of slots for selected abstracts and posters. Piotr Sicinski (2023 plenary)"en par with a Gordon conference for science and interaction" australiancellcycle.org
A transcription balance required for genome stability 🧬⚖️ Our work on RNA Pol II transcription speed control by the DNA helicase RECQL5 and the transcription-coupled DNA repair complex is now on @NatureSMB #CryoEM #transcription nature.com/articles/s4159…
🛟Wow cyclic peptides are cool! Excited to share a new publication on "Potent Cyclic Peptide Inhibitors Disrupt the FANCM–RMI Interaction". Work led by @yuhenglau to which we contributed structures and ideas. The top hits mimic native MM2...but in reverse! pubs.acs.org/doi/10.1021/ac…
I'm super excited to announce that registrations are now open for the 19th Australian Cell Cycle, DNA Repair and Telomere Workshop. Awesome international speaker line-up, with plenty of locals being invited! Book now to secure your earlybird rate. australiancellcycle.org
🚀 Scientists, it’s time for a fresh start!🧬 The Twit algorithm is now less on conversation, more on chaos... it’s time to embrace a platform that’s built for connection and collaboration. Join BlueSky and discover a space for real scientific dialogue #SciTwitter ➡️➡️#BSkySci
We are pleased to inform you that the meeting “From Genome Instability to Cancer: A tribute to Angelos Constantinou” that will take place in Carry-Le-Rouet from March 10th to March 13th 2025 is now open for registration on the link: tribute2angelos.fr/page/home/
I’m thrilled to share this preprint, in which we @BaubecLab engineer DNA damage probes to track DNA damage dynamics by live cell imaging and to probe the DNA damage-associated proteome via proximity ligation: biorxiv.org/cgi/content/sh…
Check out our latest pre-print, a follow-up to our 2022 NAR study. Now we have characterized encounters of human DNA polymerase delta holoenzymes with 10 biologically-significant & structurally diverse DNA lesions. Follow 🧵 for key findings & implications biorxiv.org/content/10.110…
In my several decades in science, few moments have been as seismic as when AlphaFold burst onto the scene (seeing the first structure of a K+ ion channel, from Rod MacKinnon, was up there too). We rushed to fold every protein we had been working on, that had no structure, and…