Irene Chiolo
@chiolo_lab
Chasing DNA repair mechanisms in heterochromatin, @USC #DNArepair #Recombination #Genomeintegrity #Heterochromatin #Nucleararchitecture
Want to better understand nuclear and genome organisation in various organisms, tissues, and cell states? Join @KarimMekhail , @altmeyerlab & Irene Chiolo at the upcoming 2nd Spatial Genome Organisation Conference this October! Talk Submission has been extended until 14th July,…
Online Now: A unified pan-cancer proteome atlas dlvr.it/TLPtvc
Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out. biorxiv.org/content/10.110… @Eric_Betzig @legant_lab
Absolutely insane amount of data in this resource from @mason_lab The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs biorxiv.org/content/10.110… Spatial data on 15million cells from 100 donors across multiple ages, mainly GI
In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput method to measure nuclear condensate formation & applied it to ~14000 IDPs to find out rdcu.be/eq975
New exciting discovery from the @chiolo_lab at @USCDornsife
New research from USC Dornsife scientists reveals how cells fix dangerous DNA damage in hard-to-repair areas of the genome. dornsife.usc.edu/news/stories/p…
Excited to share our new paper on the fascinating role of Nup98 condensates in heterochromatin DNA repair, from the @chiolo_lab, just published in @MolecularCell! Huge congrats to all the co-authors! Check it out dlvr.it/TLBMbH
Online Now: Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51 dlvr.it/TLBMbH
Hidden DNA repair system that could transform cancer treatment and slow #aging. Scientists find 'condensates' formed by the protein Nup98 help cells avoid catastrophic errors when repairing breaks in tightly packed DNA. By @anikmitraAM, @chiolo_lab,et al. doi.org/10.1016/j.molc…
Big thanks to @AgaGambus @ChowdhuryLab for their fantastic talks and to our amazing community for the rich discussions! Next up: September 9th with Ruben van Boxtel and @PoloSophie. Enjoy summer & stay in the loop 👉: docs.google.com/forms/d/e/1FAI…
Our article is online! It is showing nucleoplasmic role of a nuclear pore protein in the heterochromatin repair. One of the mechanism of genome maintenance against genotoxic stress. Congratulations @ChMerigliano and authors! Happy reading! @chiolo_lab
Online Now: Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51 dlvr.it/TLBMbH
Exciting new story from @chiolo_lab out in @MolecularCell showing Nup98 droplets driving faithful DSB repair! Big shout out to leading 💫 @ChMerigliano 🍾🍾
Wondering what is a nucleoporin doing at repair sites? Check it out in our most recent paper in Molecular Cell! dlvr.it/TLBMbH
Online Now: Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51 dlvr.it/TLBMbH
Looking very much forward to the 2nd edition of the Fusion Conference on Spatial Genome Organisation #SGO25 @Fusion_Conf @KarimMekhail @chiolo_lab. Early bird registration closes soon: June 2nd, 2025. Slots available for selected talks from abstracts: fusion-conferences.com/conference/188
When RNA damage induces DNA breaks dlvr.it/TK4l7c
Spatial multi-omics reveals cell-type-specific nuclear compartments @Nature @LongCai_Lab @yodai_takei nature.com/articles/s4158…
Excited to share our new paper out in @Nature revealing cell-type specific nuclear organization and its link to gene regulation using new spatial multi-omics technologies! nature.com/articles/s4158…