Zeyun Lu 鲁泽沄
@zeyun_lu
Research fellow @ DFCI and HMS. PhD @ USCKeck. Every day, I learn a bit in stats, genetics, and coding. Views my own.
Happy to share that our work from the @nmancuso_ lab is out in @NatureGenet! We developed SuShiE, a multiancestry fine-mapping method for molecular traits. doi.org/10.1038/s41588…
Excited to share our new preprint! CACTI boosts cQTL(or caQTL) discovery by leveraging correlation between nearby peaks, uncovering 51%-255% more signals than single-peak methods. Plus, a version of CACTI,CACTI-S, skips peak calling & works great when peak calling is challenging.
Improved chromatin QTL mapping with CACTI biorxiv.org/content/10.110… #biorxiv_genetic
Very happy to share our new paper now on @medrxivpreprint: “Genetic risk effects act in sets”, a great effort led my PhD student @JolienRietkerk, and performed together with collaborators @andywdahl, @AndrewSchork, @jonathan_flint1 etc. Thread 1/n
The method for revealing ancestry-specific structures in admixed populations is published! Many thanks to my postdoc advisor @CharlestonCWKC and the members in the lab! I'm making this method as easy to use as possible, feel free to try it out at github.com/jitang-github/…
📣New from Tang & @CharlestonCWKC! 📄A genealogy-based approach for revealing ancestry-specific structures in admixed populations cell.com/ajhg/abstract/…
This work driven by @JiTang1024 is now officially published! x.com/AJHGNews/statu…
📣New from Tang & @CharlestonCWKC! 📄A genealogy-based approach for revealing ancestry-specific structures in admixed populations cell.com/ajhg/abstract/…
A brief musical note: I’m very excited to share that my brilliant wife, a pianist and composer, has just released her debut album featuring works by Iranian women composers, including one of her own. Here is the link in case you’d like to take a listen: navonarecords.com/catalog/nv6747/
Faculty Positions in AI for Life Sciences at Westlake University nature.com/naturecareers/…
traceax: a JAX-based framework for stochastic trace estimation biorxiv.org/content/10.110… #biorxiv_bioinfo
Excited to see my PhD work published! We performed a GWAS of 19 circulating fatty acids in >239K EUR participants, identifying: 🧬 215 (70 novel) loci for PUFA traits 🧬 163 (61 novel) for MUFA traits 🧬 119 (54 novel) for SFA traits Big thanks to @yekaixiong and @xx_huifang!
It is a major PhD project of @YitangS. I am very excited to see this work out. I learned so much about the genetics of circulating fatty acids. This is a solid foundation for more research to come regarding gene-diet interactions for omega-3 and omega-6 fatty acids.
It is a major PhD project of @YitangS. I am very excited to see this work out. I learned so much about the genetics of circulating fatty acids. This is a solid foundation for more research to come regarding gene-diet interactions for omega-3 and omega-6 fatty acids.
The latest @HGGAdvances article from @yekaixiong & colleagues reports the results of a genome-wide association study that identifies additional genetic loci for 19 circulating fatty acid traits in UK Biobank participants of European ancestry: cell.com/hgg-advances/f… #ASHG
[Zhao et al., 2025 medRxiv] New pre-print asks the question: since traits are genetically correlated with each other, can we partition the heritability (h2) of a trait into a trait-specific component (unique to that trait) and a pleiotropic component (shared with other traits)?
Impressive work!
Our CACTI preprint is live on bioRxiv! It boosts cQTL discovery by 51–255% vs standard single-peak methods, and CACTI-S skips peak calling when it’s tough. Our cQTL map colocalizes with 6–47% of GWAS loci (15–424% more) and uncovers 24–75% of loci that eQTLs miss.
Racism twitter has taken to arguing that observed racial differences must be "in part" explained by genetic differences, though they demure on how much. Not only is this claim aggressively misleading, it is completely unsupported by data. A 🧵:
Scientists have been publishing climate models since ~1970. A good way to evaluate their skill is to compare what they expected to happen in the years after the model was published to observed climate changes. It turns out most models were pretty spot-on:
If you are a trainee at Harvard Medical School doing life-saving research, the government has just terminated your funding. And if you want to continue your research as an independent investigator at a different institution, the government will terminate that funding too.
The NIH notified me yesterday that there is currently no policy that supports applying for a R00 that is associated with a terminated K99. So now, both the postdoc K99 (Harvard, $250k) and the R00 (non-Harvard institution TBD, $750) are BOTH effectively terminated.
Excited to share that Ajay's paper is now out @NatureGenet : Transcriptome-wide analysis of differential expression in perturbation atlases rdcu.be/eiyI3
How do genetic perturbations change cells? How are these effects shaped by cell type and dosage? How do we best extract insight from modern massive perturbation atlases? Im pleased to share a new preprint where we develop a suite of statistical approaches to these Qs (link below)
Delighted to have our Perturb-multiome paper, led by @jmartinrufino and #AlexisCaulier from our lab, published today in @ScienceMagazine. Please check out this powerful approach to decipher gene regulatory networks enriched for genetic variation: science.org/doi/10.1126/sc…
The New York Times recently had an article on IVF and embryo selection which I think buries a few important ledes about these products ...