Vijay Sankaran
@bloodgenes
Pediatric Hematologist/Oncologist, Geneticist, Stem Cell Biologist - @HHMINEWS, @BostonChildrens, @DanaFarber, @broadinstitute
"Science" is now the third highest supported institution in the US, after small business and the military. Higher ed is fifth.
Full text is now up 🩸🧬: biorxiv.org/content/10.110…
Delighted to have our preprint led by @lvchosen1 up: Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells biorxiv.org/content/10.110… 🧵 below ...
I'm excited to share work on a research direction my team has been advancing: connecting machine learning derived genetic variant embeddings to downstream tasks in human genetics. This work was led by the amazing @divyanshi91! biorxiv.org/content/10.110…
New preprint: teaching single-cell foundation models to learn from perturbations in collaboration with @madduri & @RUNX1Research supported by @cziscience. Closing the loop identified a target for RUNX1-FPD now in Ph2 trials 🔗biorxiv.org/content/10.110… 🧵by @yash_persh👇
We are excited to share our work on "closing the loop" 🔄 - a framework enabling single-cell foundation models (scFMs) to learn from experimental validation and dramatically improve their predictive accuracy! (1/n)
Check out this valuable review from @TrowbridgeLab, Xiurong Cai, and Bobby Bowman!!! 👇👇
Delighted to share an updated review and our perspectives on clonal hematopoiesis and cancer in @NatureCancer in collaboration with Xiurong Cai and Bobby Bowman: rdcu.be/ewN62
Beyond excited to share our #NewPaper in @CellCellPress! Inflamed environments acidify intracellular pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of inflammation. #inflammation #pH authors.elsevier.com/sd/article/S00…
Wow!!! Big advance for women with pathogenic mitochondrial DNA variants in @NEJM! nejm.org/doi/full/10.10… nejm.org/doi/full/10.10…