Lili Wang
@liliw_wang
Research fellow @DanaFarber/@harvardmed with @SashaGusevPosts. PhD @UChicago with @XuanyaoLiu. Statistics, genetics, statistical genetics.
Our work led by @liliw_wang on identifying trans genetic effects of gene networks is out in @CellGenomics today!
Trans-eQTL mapping in gene sets identifies network effects of genetic variants dlvr.it/T4w67y
Our CACTI preprint is live on bioRxiv! It boosts cQTL discovery by 51–255% vs standard single-peak methods, and CACTI-S skips peak calling when it’s tough. Our cQTL map colocalizes with 6–47% of GWAS loci (15–424% more) and uncovers 24–75% of loci that eQTLs miss.
Excited to share our new preprint! CACTI boosts cQTL(or caQTL) discovery by leveraging correlation between nearby peaks, uncovering 51%-255% more signals than single-peak methods. Plus, a version of CACTI,CACTI-S, skips peak calling & works great when peak calling is challenging.
Parts of it may well be deemed "outdated". But the reason college curriculum is structured as it is instead of being a grand industry tour on the Hot Topic Of The Day is that by teaching fundamentals, you teach students *how* to think, learn, and work. AI just bypasses that.
Now, you can ask: "what if my tasks at work are simple enough to where GPT does solve it all, easily? Can't I just use it for that?" Congratulations. You may have discovered the path to being unemployed. If the AI does everything you can do, *why would they keep you around*?
This is such an accurate representation of being a PhD student
Excited to share our work on alternative splicing (AS) rdcu.be/dSHtu. This version, compared to the biorXiv one, is much more succinct due to word limits; I hope you will have a look. Congrats to @BenjaminFair3 and @cfbuenabad for their incredible work!🧵⬇️
My lab at @UChicago has an open postdoc position. AT #ASHG2023 AND interested in Statistical genetics and functional genomics? Please reach out and let's chat!
Postdoc fellow- Computational Biology, University of Chicago @XuanyaoLiu Come join us at #UChicago as a #bioinformatics postdoc, working on #human genetics and #functional genomics. jobrxiv.org/job/university… #ScienceJobs #job #genomics #postdoc #UC...
Excited to be heading to DC for #ASHG2023! Interested in chromatinQTL calling and trans gene regulation? Check out the talk and posters from our group @liliw_wang, @NikitaBabushkin and Jinghui Li.
Really pleased to share our latest work on alternative splicing (AS). This has been long in the making and would not be possible without the hard work from two extremely talented scientists @BenjaminFair3 and @cfbuenabad. Feedback welcome! 1/6
Cryptic splicing mediates genetic and therapeutic perturbation of human gene expression levels biorxiv.org/cgi/content/sh… #bioRxiv
First lab paper on preprint! @Lianyun_Huang worked out the genetic differences between MDD symptom assessed through the PHQ9 and CIDI-SF, see her thread here:
I'm thrilled to share my first preprint on genetics of MDD symptoms assessed with PHQ9 and CIDI-SF in UKB: we find that PHQ9 better index general dysphoria in the general pop, while CIDI-SF better captures MDD heterogeneity in a clinically enriched one medrxiv.org/content/10.110… 1/n
Congrats Minhui!
New preprint! Together with @andywdahl , we develop CTMM (Cell Type-specific linear Mixed Model), a novel method for scRNA that detects cell type-specific gene expression from a new angle compared to standard tests for Differentiatlly Expressed Gene (DEG). biorxiv.org/content/10.110…
super excited to share our new paper on polygenic epistasis! we introduce a new model and show how structured statistical epistasis can help us study complex trait biology. huge thanks to my friend and lab-mate @studyjeromics, and my mentor @andywdahl! biorxiv.org/content/10.110…
Super excited to share our new manuscript!!
Thrilled and proud to share our work on a powerful and flexible method that detect trans-eQTLs of gene sets/pathways, led by @liliw_wang! biorxiv.org/content/10.110… We previously predicted that trans-eQTL effects may explain the omnigenic nature of many complex traits, but..
@liliw_wang on trans-PCO: a powerful approach to detecting trans-eQTL associated with regulatory network #ashg22
I am very proud to share our work, titled: “Allele frequency differences of causal variants have a major impact on low cross-ancestry portability of PRS“,(medrxiv.org/cgi/content/sh…)
Following the Nov. 9 murder of UChicago alum Shaoxiong ‘Dennis’ Zheng, President Paul Alivisatos shares a video message with our community on the University’s commitment to addressing violence in the city. Watch Here: ms.spr.ly/6015knjSW
Come do a postdoc in statistical genetics with Xuanyao and me at Uchicago! Possible project areas include omnigenics, gene-context interaction, and/or more equitable genetic prediction. Please do reach out for a chat if you are interested :)
@andywdahl and I @Uchicago are jointly looking for a postdoc to work on computational methods to study functional genetic variations causing diseases. If you want to chat, please feel free to contact me or @andywdahl ! Please help retweet! #postdocjobs
@andywdahl and I @Uchicago are jointly looking for a postdoc to work on computational methods to study functional genetic variations causing diseases. If you want to chat, please feel free to contact me or @andywdahl ! Please help retweet! #postdocjobs
1. Read every (working) day. 2. Create a database of readings with full citation, main argument/findings, critiques, and notes on use. 3. Maintain 2. 4. Get in on your fields social media, it will be useful. 5. Start thinking about how to mine your research for publications early
There’s a lot of interest right now for learning bioinformatics skills while lab research is suspended and everybody is working from home. I wanted to share *free* resources for learning coding basics and field-specific materials. Thread (1/n)