Jian Yang
@jyang1981
Professor of Statistical Genetics, Westlake University
A single-authored research highlight paper from our PhD student Liyang SONG is out now in Nature Review Genetics. @liyang_song
New online! Mapping trait-associated cells with spatial transcriptomics bit.ly/44PKnBR
gsMap paper online. Source code: github.com/JianYang-Lab/g…. Results visualisation website: yanglab.westlake.edu.cn/gsmap.
Nature research paper: Spatially resolved mapping of cells associated with human complex traits go.nature.com/4c3EAvv
SMR Portal: an online analysis, visualisation, and database platform for mapping complex disease genes. Powered by Westlake FutureGene. Try it out at: yanglab.westlake.edu.cn/software/smr_p…. See a tutorial video at: yanglab.westlake.edu.cn/software/smr_p…
Faculty Positions in AI for Life Sciences at Westlake University nature.com/naturecareers/…
Research Highlight by Lin Tang: nature.com/articles/s4159…
This study shows that lowland individuals living at high altitude exhibit accelerated DNA methylation age. nature.com/articles/s4142…
The SMR Portal paper is now online. nature.com/articles/s4159…
*Ten* 3-year post-doc/assistant prof jobs advertised for our Pioneer Centre for SMARTbiomed - address key questions in common complex diseases through development of new stat/comp tools & software. A new Denmark-Oxford collaboration. Critical mass! smartbiomed.dk/join-the-centr…
From genetic associations to genes: methods, applications, and challenges: Trends in Genetics cell.com/trends/genetic…. A review paper from a team effort led by Ting @TingQi2
“The extent to which MR methods are robust to directional pleiotropy can vary depending on the specific method used. This underscores the importance of comparing different MR methods in real data analysis before making definitive inferences about causality.” Well done, Angli!
I'm so excited the last piece of my PhD work is finally out! In this study, we unravelled the complex causal relationship between substance use behaviours and common diseases by Mendelian Randomization, genetic correlation, and dosage-dependent analyses. nature.com/articles/s4385…
Naomi Wray (@WrayNaomi) works at the interface of genetics, statistics and psychiatric disorders. With early training in quantitative genetics applied to livestock she brought to the field a perspective on the polygenic nature of common complex disease 🧬 cell.com/neuron/fulltex…
New GCTA version compatible with Apple M1 and M2 chips (ARM architecture). yanglab.westlake.edu.cn/software/gcta/…
This is how I advise my #PhD students to write research manuscripts (in case someone finds it helpful). General points: 1. Research questions addressed by your manuscript are key and should guide you. 2. Don’t view your manuscript as an article. See it as a STORY. 3. Pick the…
The advantage of rare variant analysis? It often leads us straight to the causal variants/genes. As WES/WGS data continues to grow, we anticipate a wave of new therapeutic target genes to be discovered for #obesity and other complex diseases. cell.com/cell-genomics/…
A new method to find the most relevant cells for a complex trait by integrating GWAS summary statistics with scRNA-seq data. Great work led by my collaborators, Dr. Yunlong Ma and Prof. Jianzhong Su.
Polygenic regression uncovers trait-relevant cellular contexts through pathway activation transformation of single-cell RNA sequencing data dlvr.it/Strt4g
This study elucidates the mechanism behind why individuals born to older mothers tend to be larger. Excellent collaborative work led by my colleague Dr. Lianfeng Wu! nature.com/articles/s4142…
Buckle up! We're in for a wild ride today. A new @NatMetabolism paper by scientists from China adds a surprising twist to the long-known FTO GWAS story. The FTO locus (16q12.2) is the first ever GWAS locus to be associated with obesity and even after 16 yrs now, scientists…