Haoyuan Wang
@wanghychemistry
I love soccer (Go ManU!), chemistry and biology PhD'2017 at UW-Madison/Prof. Weiping Tang Postdoc (2017-2022) at UCSF/Prof. Jack Taunton All views are my own
Targeted degradation of extracellular secreted and membrane proteins - ScienceDirect sciencedirect.com/science/articl…
New publication of a retrospective study of ADC after ADC! Not surprisingly, for HER2-positive: “Patients who received ADC2 with a different payload from ADC1 exhibited significantly longer PFS2 (6.8 vs. 2.7 mo) and overall PFS (15.0 vs. 8.5 mo)”
As a student, I was inspired to pursue a career in pharma by reading about the amazing synthetic chemistry innovations that were happening there. I hope this article can do the same for the next generation of pharmaceutical chemists. #MerckChemistry pubs.acs.org/doi/10.1021/ac…
It’s easier to distance yourself from these horrific tragedies and put up a barrier when they happen across the country, but it’s extra chilling when it is quite literally so close to home. We can’t desensitize ourselves to SCHOOL SHOOTINGS. This cannot keep happening
#BREAKING reports of a school shooting at Abundant Life Christian School in Madison. We just arrived on the scene.
Most MIT profs who I know are extremely honest and morally upright. I hope this is an exception.
Mitigating racial bias from LLMs is a lot easier than removing it from humans! Can’t believe this happened at the best AI conference @NeurIPSConf We have ethical reviews for authors, but missed it for invited speakers? 😡
Atlas Venture's 2024 Year In Review Here's our state of the industry talk for 2024. Interesting times, indeed. Covers innovation & impact, the investment climate, and a brief update on Atlas itself. lifescivc.com/2024/11/atlas-… #biotech @atlasventure youtube.com/watch?v=szwRUE…
The price of a Costco Hot dog🌭 every year since it was introduced: 1984: $1.50 1985: $1.50 1986: $1.50 1987: $1.50 1988: $1.50 1989: $1.50 1990: $1.50 1991: $1.50 1992: $1.50 1993: $1.50 1994: $1.50 1995: $1.50 1996: $1.50 1997: $1.50 1998: $1.50 1999: $1.50 2000: $1.50 2001:…
The UN has verified more than 250 attacks on health care facilities in Gaza and the West Bank, including hospitals, clinics, ambulances and patients, with five hospitals hit in the last week alone, according to the director general of the UN's WHO. nyti.ms/3QTmbsh
Great work, congrats!
Super excited to share my first postdoc preprint with @realJimWells ! In this manuscript, we introduce MultiMap, an interactome profiling method with adjustable resolution that enables short, intermediate and long range labeling from a readily available photocatalyst.
Merck & Co.’s PCSK9 inhibitor MK-0616 showcases the potential of macrocycles as oral drugs for extracellular targets, and companies are also exploring intracellular and macrocycle–drug conjugates - find out more in this news article published today bit.ly/3Pf0i4B
The founder and former CEO of Vertex Pharmaceuticals, Joshua Boger, was once asked: "What does it take to be a good leader in a pharmaceutical company?" Boger said, "Pharmaceutical discovery and development is the most complicated activity that humans do. Going to Mars is easy,…
Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control: Cell cell.com/cell/fulltext/…
Peptides that bind MHC Class I are readily identified with a programmable, high-throughput method go.nature.com/3GzQsaD
Congrats, Kevan!!!
Incredibly honored to receive this recognition of our lab’s work on KRAS(G12C) especially @JonathanOstrem and Ulf Peters who teamed up to drug the undruggable. Thanks @frankpmccormick for introducing me to the beating heart of cancer. @UCSFCancer @HHMINEWS @KRASKickers
A curious story on gaming and patent-prolonging strategies. nytimes.com/2023/01/28/bus…
Introducing N-methylation into peptides can be accomplished by using N-methylated amino acid building blocks. But site-selective N-methylation of peptides on resin is also possible. pubs.acs.org/doi/10.1021/ja…
I'm delighted to present this story from the Taunton lab @UCSF in its final form! authors.elsevier.com/a/1gPf4L7PXiq%…
Gravely concerned about the earlier incidence and disproportionate and escalating mortality of Colorectal Cancer in young adults. Must screen earlier, systematically. Must understand and influence exposure (food, alcohol, other). What is needed @NCIDirector and @KimmieNgMD?
✳️Colorectal cancer is now the leading cause of cancer related death among males aged 20-39 and 40-49 ‼️It was third among 20-39 age group last year. ✳️ Concerning trend is also seen in young women; CRC related death and will likely surpass breast cancer in near future @OncoAlert
Cool drug-induced degradation of translation elongation and termination factors to rescue stalled ribosomes out in @CellCellPress! Congrats to our @UCSF neighbors @keely_oltion @MartinUCSF and Jack Taunton!!! cell.com/cell/fulltext/…
On behalf of his loving family, and with a heavy heart, I’m sad to report the passing of Yoshito Kishi, a towering figure in organic chemistry. In addition to his transformative research, Yoshi will be forever remembered for his warmth, generosity, and deep sense of humanity.