Weiping Tang
@tang_weiping
Drug discovery faculty at UW Madison School of Pharmacy
Researchers @tang_weiping @UWMadPharmacy develop Folate Receptor Targeting Chimeras (FRTACs) to specifically target proteins in cancer cells, aiming to reduce on-target, off tumor toxicity. nature.com/articles/s4146…
🚨 In a new publication in @Nature Communications @tang_UWMadison and collaborators developed a new type of molecule called folate receptor targeting chimeras, representing a new approach to treating #cancer. nature.com/articles/s4146…
If you're passionate about medicinal chemistry, drug discovery, and teaching the next generation of scientists, consider joining the School of Pharmacy as an assistant professor of pharmaceutical sciences! Find more details and apply 🔽 jobs.wisc.edu/jobs/assistant…
For readers interested in approaches for extracellular targeted protein degradation, here's a comprehensive review bit.ly/489BXVZ rdcu.be/dLaX8
A new preprint led by @YunruiQ! Using IGME non-Markovian models, we identified non-canonical PPIs between KRAS and VHL for PROTAC design. A top-ranked PPI aligns well with a co-crystal structure from an experimentally designed PROTAC with potent efficacy! go.shr.lc/3yUU6dz
Thanks to the Research Forward scheme for funding our development of a chemical feature-based Transformer platform to predict molecular glues! Excited to collaborate with @SharonYixuanLi and @tang_weiping. Our 1st grant in targeted protein degradation! research.wisc.edu/a-novel-deep-l…
Congratulations to DSI Affiliates @SharonYixuanLi and @XuhuiHuangChem on receiving a Research Forward award. Li, Huang, and Weiping Tang will create a deep learning platform to identify molecular glues that can degrade proteins associated with cancer. research.wisc.edu/a-novel-deep-l…
The November special issue of @TrendsinPharma features advances in TPD strategies and opportunities Many thanks to the authors @tang_weiping @danetteldaniels @behnamnabet @fredhutch @BLZerf6 @LynJonesChemBio @FassLab @WeizmannScience @gpsapkota @keserulab @matoseviclab
Targeted degradation of extracellular secreted and membrane proteins - ScienceDirect sciencedirect.com/science/articl…
Development of Potent and Selective Coactivator-Associated Arginine Methyltransferase 1 (CARM1) Degraders | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…
A Modular Chemistry Platform for the Development of a Cereblon E3 Ligase-Based Partial PROTAC Library (W. Tang et al.) @tang_weiping onlinelibrary.wiley.com/doi/10.1002/cb…
We're proud of Christopher Stevens, School of Pharmacy PhD student in Pharmaceutical Sciences—selected for a @UWMadGSEd Graduate Student Service Scholarship for exceptional service contributions to the university outside of his research with @tang_weiping. bit.ly/3LMtteM
Lauren Rault, an undergraduate chemistry student working in the lab of Professor Weiping Tang, has earned an Undergraduate Award in Organic Chemistry from the @AmerChemSociety! Rault is being recognized for her coursework and research accomplishments in the @tang_UWMadison Lab.
The E3 ligase adapter cereblon targets the C-terminal cyclic imide degron nature.com/articles/s4158…
BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
Antibody targeting of E3 ubiquitin ligases for receptor degradation @genentech nature.com/articles/s4158…
Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins go.nature.com/3R6V2ix
A review paper on PROTAC delivery with my colleague.
It was a great pleasure to co-write this tutorial review with my colleague @tang_weiping to share our thoughts on how to advance clinical translation of PROTACs through drug delivery system design. @UWMadPharmacy pubs.rsc.org/en/content/art…
Our modeling work on PROTAC-Mediated Ternary Complexes pubs.acs.org/doi/10.1021/ac…
Our new PROTAC synthesis platform is online. authors.elsevier.com/a/1eshaoqiQAjm…