Stuart Schreiber
@SchreiberStuart
Truth-seeking scientist; equal parts Cajun, Mississippian, Irish, Hungarian.
1/4 A Perspective on proximity-inducing #molecularglues and bifunctional compounds in relation to hot-spot-associated missense mutations enshrined by natural selection and posttranslational modifications (PTMs). chemrxiv.org/engage/chemrxi…
Bravo Damian!
I am extremely grateful to be awarded a $5,000,000 Catalyst Grant from the Welch Foundation. This grant will be focused on further developing the science of DNA-Encoded Libraries (DELs) for generating small molecule ligands toward a broad spectrum of disease-related targets.…
Excited to see this dynamic duo tackling high-impact biomedicine – among others, AI for reasoning on human evidence and AI for informed therapeutics forbes.com/sites/sindhyav…
Outstanding @morgancheatham @NEJM_AI
The arc of technological progress in health care is nearly limitless — yet AI’s potential remains out of reach. On the latest @NEJM_AI GrandRounds, @morgancheatham breaks down what’s standing in the way of real impact. Full episode: nejm.ai/ep28
Under this ownership group, the Celtics won two championships and built a culture of camaraderie and resilience. Steve's deep loyalty to Boston makes him a champion both on and off the court, leaving a legacy that will forever inspire Celtics fans and Bostonians alike.
Here's my statement on today's news.
From @m2jr in Pattern Breakers (quote from William Gibson): "The future is already here; it's just not evenly distributed." What's true of technology is true of medicine – we need insights into the inflection points to unlock transformative biotechs #SXSW2025
It’s go time for @SXSW! 🚀...today with Jim Breyer I’m excited to share the stage this afternoon with my longtime friend and one of the best in the business, @jimihendrixlive, to explore the forces that drive startups to outlier success. Join us on the main stage (Salon H) at…
Heartfelt congratulations, Jiaqi and Smriti, on this well-earned recognition. I'm proud to have my name associated with yours.
Congrats to the winners of the Stuart L. Schreiber Prize in Scientific Excellence presented at the @broadinstitute 's annual retreat! @JiaqiZhangVic (top) won for outstanding work on causal inference AI and @Smriti__Pandey (bottom) for pushing the frontiers of genome editing.
Scientists create vast library of compounds to target disease proteins phys.org/news/2025-01-s…
biorxiv.org/content/10.110… Compounds that recruit FKBP12 to novel targets with high cooperativity are the prototypical molecular glue and, represented by sirolimus and tacrolimus, have had major clinical impact. 1/3
PUFAs provide membrane fluidity and promote extravasation, but also result in vulnerability to a ferroptotic grease fire:
We are delighted to share the most recent work from our lab at Westlake University: ACSL4 and polyunsaturated lipids support metastatic extravasation and colonization: Cell cell.com/cell/fulltext/…
@HowardYChang is a phenomenal choice for the CSO role at @Amgen. Kudos to @jaybradner for shooting for the stars and recruiting a star scientist to his R&D leadership team. Together, they will transform science at @Amgen.
Amgen's $AMGN incoming CSO & SVP Research @HowardYChang was awarded the 2024 Lurie Prize in Biomedical Sciences by the Foundation for the National Institutes of Health med.stanford.edu/news/all-news/… for his research into the role of long noncoding RNAs — genetic sequences that…
Learning from the Generative AI community and exploring opportunities to interface with human biology at the Liquid AL Conference at MIT – a promising frontier
I had a fantastic time at the @LiquidAI_ conference in Boston this week. We're just scratching the surface of what I believe will revolutionize nearly every aspect of society. For a quick recap, check out @TheAiGrid’s summary here: youtu.be/FsFvDHSgG_s. There’s a lot to…
Everybody gets angry. But don’t stay angry. Anger is counter-productive. Instead, be motivated by a desire to help others and . . . Love, Family, Country, Compassion, and Mastery. #PlayNiceButWin
First-time dad Travis Blum knows that bringing something new into the world is hard, messy work, and about the most rewarding thing a person can do. He reaches beyond his job description to help in any way he can, his apologetic smile forever signaling regret for time's finitude.
Inspired by findings from @TSharifnia & @SchreiberStuart that GPX4 is essential in chordoma, we’ve demonstrated that GPX4 inhibition induces ferroptotic cell death, suggesting ferroptosis susceptibility may be a targetable vulnerability in chordoma. Results now on @figshare.…
Proximity-inducing #molecularglues for RAS- and RAF-dependent cancers
A Brain-Penetrant pan-RAF–MEK Non-Degrading Molecular Glue for Untreated RAS- and RAF-Driven Cancers Read the full article to learn about NST-628’s fascinating MoA, how it differentiates, why this molecule is a big deal, and more! LINK | drughunters.com/4dwpD4I
Hallmark of oncogenic mutant p53? Exceptionally high levels of expression. How to exploit for treating cancers? A bifunctional Chemical Inducer of Proximity (CIP) that targets a cytotoxic small molecule to mutant p53 cancers. See thread by @wgibson
TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules
Polyglot Giulia Oliva speaks English, Greek, French, and her native Italian. She would love to learn more but is busy with another manner of translation—turning her splendido mind to generating insights in the lab that she hopes to translate to new ways of treating disease.
Cool story from @leilei_wuu on Broad scientists that made a new, compact #epigenetic editing tool small enough to fit in an #AAV to tackle deadly prion disease. They did such a good job at making it small, the AAV expert told them to add some filler! endpts.com/to-tackle-a-de…
#Perspective #Featured #OpenAccess from @SchreiberStuart at @arenabioworks @broadinstitute: on proximity-inducing molecular glues and bifunctional compounds, drawing analogies to hot spots, missense mutations, and posttranslational mods dlvr.it/T8b5hQ
Inhibiting PRDX6 to induce #ferroptosis may be a compelling target for #cancer therapy. Beautiful study from one of the most beautiful cities in the world, Kyoto. Profs Iwai and Fujita, thank you for elucidating this part of the cancer - ferroptosis link. nature.com/articles/s4159…