Nature Biotechnology

An engineering strategy that allows the reversible engraftment of gut microbes is used to build a therapeutic candidate for reducing hyperoxaluria science.org/doi/10.1126/sc… #NBThighlight

Optical pooled screening is enhanced by amplification of barcodes before in situ sequencing go.nature.com/3ZVzqOi rdcu.be/exfh0

In Brief: @US_FDA approves @GileadSciences' #Yeztugo, a drug that almost completely protects against HIV-1 infection and only needs to be given twice a year nature.com/articles/s4158… rdcu.be/exop0

A new impact framework for investors in life sciences bridges financial returns and patient outcomes go.nature.com/3TV0pFr

Combined single-cell profiling of chromatin–transcriptome and splicing across brain cell types, regions and disease state go.nature.com/3IKlcJn

🚨New Forum podcast just dropped🚨 Barbara Cheifet speaks with Marie Lopez and Brian Hie about how foundation models are being used for analysis of the function and structure of DNA, RNA and proteins, and how they're being developed for clinical use shows.acast.com/forum/episodes…

SPLASH2 speeds up analysis of sequence variation in massive datasets go.nature.com/3N1SGBL rdcu.be/exfhL

Experts disagree about the extent to which hybrids based on dire wolves reflect the original extinct species, and the broader role of de-extinction technologies in ecosystem restoration nature.com/articles/s4158…

The strength and importance of government-funded patents for approved drugs go.nature.com/3UmMtnL

A bit late, but excited to announce our new paper, "Defining and benchmarking open problems in single-cell analysis," a joint effort led by our team (@scottgigante, @DBBurkhardt ) at @Yale and the @fabian_theis and @MDLuecken at Helmholtz! 🚀 **Open Problems**, is a living,…

Out in @NatureBiotech: Metagenome taxonomy profilers usually ignore unknown species. SingleM is an accurate profiler which doesn't, even detecting phyla with no MAGs. Profiles of 700,000 metagenomes at sandpiper.qut.edu.au. doi.org/10.1038/s41587… A 🧵

Our paper is now in @NatureBiotech! Topological velocity inference from spatial transcriptomic data. TopoVelo infers the direction of differentiation/migration; quantifies spatial cell influence; and identifies morphology changes during differentiation. 🧵rdcu.be/ewqMB

Three undeniable geniuses in biomedical research and innovation @DaphneKoller @NoubarAfeyan @EricTopol talk about the impact of generative AI today and in the future, on the "AI Revolution in Medicine, Revisited" podcast @MSFTResearch microsoft.com/en-us/research…

Designed protein domains can selectively target intrinsically disordered regions, potentially generating binders for key proteins in biological function and disease. science.org/doi/10.1126/sc… #NBThighlight

In Brief: In one of the biggest biopharma deals of 2025, @sanofi acquires @BlueprintMeds for $9.1 billion upfront nature.com/articles/s4158… rdcu.be/ewDp6

Engineered autoactive immune receptors trigger broad-spectrum disease resistance in plants nature.com/articles/s4158… #NBThighlight