Sri Kosuri
@srikosuri
Cofounder & CEO, @octantbio ; BoD @Ginkgo ; Previously Associate Professor, @uclachem
We've started IND-enabling studies on a small molecule corrector for Rho-associated autosomal dominant retinitis pigmentosa (Rho-adRP). I thought it would be fun to spend some time walking through our approach and why we are excited. Long 🧵1/
Omg. Please let this be what I think it is. Biotech needs some of its glam back.
Happiness is contagious.
So excited to launch our 1st reagent products at Ginkgo!! We've built a ton of amazing biology tools over the years -- awesome to get them in the hands of researchers! Free samples at the link below if you'd like to try out our cell-free protein synthesis system!! 😀🧬 🧬
Cell-free protein synthesis systems, optimized at Ginkgo and now available to you! Ginkgo has been using cell-fee protein synthesis systems in house for years, and we’re now making our E. coli system available to outside users! We’ve optimized it for: • High production from…
Congress is one of the last places that can stop the proposed cuts to American science. Send them your thoughts! #ProtectScience #InnovationMakesAmericaGreat ProtectScienceAndInnovation.org
I can’t get this line out of my head since reading it at the end of the abstract for this paper: “Sleep, like aging, may be an inescapable consequence of aerobic metabolism.” nature.com/articles/s4158…
Building a human ear on the back of the mouse, 3D printed bone regeneration scaffolds, and human liver-on-a-chip, were warm-ups for building a human endometrium in lab. Want a difficult problem that is the root of women's health? Study menstruation. 🧵news.mit.edu/2025/mit-launc…
This is a *pretty amazing* paper--really fascinating implications for those who wish the field would finally begin to look into #cellbio cell.com/cell-metabolis…
Man, phishing attempts are getting pretty good (fake email from a board member, but I went directly to text where it was cleared up). Anyways, now I have their bank and routing numbers. Who do I report it to?
New preprint with Guy Sella on the question: what is polygenicity? biorxiv.org/content/10.110…
America will cease to be exceptional if the world’s best AI researchers can’t even be in the country
It is a major policy failure that the US cannot accommodate top AI conferences due to visa issues.
🧵1/Today, we published a key milestone towards AI based cardiac screening in Nature. doi.org/10.1038/s41586… EchoNext outperformed cardiologists and found thousands of high-risk patients missed in routine care. We also made a version available to the world.
To the 23andMe Community, I am incredibly excited and humbled to share with you that TTAM Research Institute (TTAM), a new non—profit medical research organization that I founded and lead, has completed the acquisition of 23andMe. I formed TTAM and pursued the acquisition of…
I've observed @markwbudde since the early days. Even then, he understood the need and was willing to do the tedious work of building an excellent operation and business first, which is rare. Love seeing all the scientists who are enabled by their products now.
Had a great chat with @fiftyyears telling the @plasmidsaurus story for their new Happy Warriors series. At Caltech, I was so frustrated with the stagnant DNA sequencing industry that I started a company out of my garage. Now we accelerate science around the globe, every day.
Awesome new offering from Ginkgo Datapoints -- we will price match any ADME service quote you get (including from Chinese or other international vendors). We plan to have the best per-compound pricing out of the gate anyway --our automation at Ginkgo allows best in class…
We’re excited to launch a powerful new capability at Ginkgo Datapoints: high-throughput, low-cost ADME profiling—optimized for machine learning from day one. Whether you’re prioritizing small molecules or training predictive models, early access to rich ADME data can…
For a platform therapeutics company as technologically rich and fast-moving as Manifold Bio, a website is always just a snapshot in time. But I’m especially excited about this one. Our goal was to capture the scale of the tissue-targeted medicines opportunity and the uniquely…
We're live! Manifold Bio's new website is here: manifold.bio Inspired? We're growing—join us. Special thanks to @bunsenstudio for articulating our vision and Javelin Tea Creative (javelinteacreative.com) for capturing the spirit of our team. #Hiring
We’re excited to launch a powerful new capability at Ginkgo Datapoints: high-throughput, low-cost ADME profiling—optimized for machine learning from day one. Whether you’re prioritizing small molecules or training predictive models, early access to rich ADME data can…
Although I am very pro-automation, I often roll my eyes when I see people talk about “automating science” in biotech Any serious conversation here needs to consider the way new methods are invented and scaled
I worry the pendulum has swung too far towards generalists over specialists, sacrificing wisdom for speed. Resulting in either boring consensus or unserious hype. There is such a thing as deep technical craft, but I’m not sure you can understand if you’ve never done it yourself
The interesting thing about having a betting market on your current employment is that you could use it as a hedge.
🚀 how good is Grok-4 on biomedical applications ? Yesterday, @xai benchmarked Grok-4 on our Chest Agent benchmark—and it crushed it. With 72.8% accuracy, Grok-4 outperformed our MedRAX (63.1%) (the previous STOA) and all other models in chest X-ray interpretation. 🔗 MedRAX:…