Lyssiotis Lab
@LyssiotisLab
Cancer and Immune Metabolism Research Laboratory @UMRogelCancer, @UMPhysiology, @UMICHpancreas
🔥Smoking hot new paper and tweetorial from @DJCalebC (collab with @ArulChinnaiyan)! 🔥 We are over the moon about this new work and its therapeutic implications for pancreatic cancer. Please have a read and share your thoughts/feedback! 🙏🏼
Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@LyssiotisLab @ArulChinnaiyan), has just been published in @Nature! @UMRogelCancer @UMICHpancreas @UMichMedSchool @UMichPath @UMichResearch @UMichCMB
Giant study finds a research field that’s mostly reproducible. That the majority of findings look verifiable speaks to the power of the scientific method, excellence of peer review and the integrity of researchers worldwide. Something we know all along. nature.com/articles/d4158…
A fascinating paper published in @Nature just two days ago offers a new perspective on sleep drive—through the lens of mitochondria. This paper shows how waking and sleeping oppositely change mitochondrial fusion and fission dynamics; how artificially manipulating fusion and…
If you are in the Midwest and ❤️ metabolism, take note! This year’s Midwest Metabolism meeting will be held jointly with the Translational Research in Mitochondrial Metabolism in Aging and Disease (TRiMAD) conference. The combined 2-day event will be @umichmedicine, with…
Lays potato chips and Tostitos are not healthier for you now. These conmetic swaps are a boon for corporate machines who get to claim "now healthier" meanwhile the calories, nutritional impacts, and excess will simply continue.
.@PepsiCo just announced it will eliminate artificial colors and flavors from Lay’s and Tostitos by year’s end—and expand the use of avocado and olive oil in place of canola and soybean oil. I urge every other food company to follow their lead and join the movement to Make…
1/ 🚨 Our new paper is online in @Nature ! As its first author, I’m enthusiastic to finally share it with you all!🎉 🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤 👉 nature.com/articles/s4158… @OxfordDPAG 🧵👇
Thomas J. Wang, M.D., chair of Internal Medicine at @UTSWMedCenter, has been named the next dean of the U-M Med School, effective Sept. 15. He brings nationally recognized leadership in academic medicine to a community rooted in care, research & education. michmed.org/kVvNe
Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔 🚨In new work out today in @NatMetabolism, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s4225… 1/n
A large study including more than 130,000 people in the U.S. revealed that the shingles vaccine (Shingrix) and the respiratory syncytial virus (RSV) vaccine (Arexyv) are associated with a reduced risk of dementia. sciencealert.com/huge-study-rev…
Registration is open (and free) for this year's Midwest Metabolism/Translational Research in Mitochondrial Metabolism in Aging and Disease (TRiMAD) Annual Conference at the University of Michigan November 10–11, 2025. Hope to see you there! vai.org/event/2025-mid…
Looking forward to a great evening tomorrow supporting Sky Foundation! Raising awareness for pancreatic cancer research & treatment. Come see us in West Bloomfield! skyfoundationinc.org Here's a sneak peak from the Rogel and Blondy Center....... @LyssiotisLab @UMRogelCancer
This may be a very powerful approach. “Analyzing the differences between old and young animals revealed a net decline in mitochondrial activity in most tissues with age, most notably in samples from the brain and metabolic tissues.”
Measuring mitochondrial respiration in frozen tissue samples provides the first comprehensive atlas of how ageing affects mitochondrial function in mice. 🔗 elifesciences.org/articles/10519…
Share a 10/10 album, a no skip trip👇🏻 I’ll start:
“Oh I avoid plastics, this is why I drink from a can” You mean the plastic bag in your can?
Awesome new preprint from Christine Chio's group @Chiolaboratory on the role of Iron-regulating signaling in cancer cachexia! A new mechanism fueling adipose browning in cachexia.... biorxiv.org/content/10.110…
BRD4 acts as a pH sensor to tune inflammation bit.ly/3IOIyNU
MAHA reflects a real frustration of people on the nutrition-related chronic disease failings of America. But it couldn't be more crystal clear that the administration sees MAHA as a tool to distract and score political points without actually making progress. Asking candy and ice…
"I have been speaking to @CocaCola about using REAL Cane Sugar in Coke in the United States, and they have agreed to do so. I’d like to thank all of those in authority at Coca-Cola. This will be a very good move by them — You’ll see. It’s just better!" –President Donald J. Trump
Smartphone alerts of preshake warnings for 2.5 billion people in 98 countries countries over the past 3 years @ScienceMagazine science.org/doi/10.1126/sc…
I can’t get this line out of my head since reading it at the end of the abstract for this paper: “Sleep, like aging, may be an inescapable consequence of aerobic metabolism.” nature.com/articles/s4158…
