BryanRoth
@zenbrainest
James Black: 'the prismatic qualities of the assay distort our view in obscure ways and degrees'
Congrats to the team: especially @gori7873 and Brian Krumm from @RothLabUNC and Adrien and Matan from Greg Scherrer's lab!! A ton of work! Structure-guided design of a peripherally restricted chemogenetic system: Cell cell.com/cell/fulltext/…
Chemogenetic and optogenetic strategies for spatiotemporal control of split-enzyme-based calcium recording biorxiv.org/content/10.110… #biorxiv_neursci
We're thrilled to announce that ISRP 2026 abstract submission will open on August the 15th! Join us in New Orleans from Feb 27 - Mar 1 Oral presentations will be 15 min + 5 min Q&A Stay tuned for more updates! Please note only ISRP members are eligible to submit an abstract
My take on the head-twitch response to test #psychedelic drugs in animals: open.substack.com/pub/zendudest/…
Distinct role of claustrum and anterior cingulate cortex bidirectional circuits in methamphetamine taking and seeking nature.com/articles/s4146…
Cool!! Another use for BMB-101!! "5-HT2C receptors in the nucleus accumbens constrain the rewarding effects of MDMA" nature.com/articles/s4138…
1/ Just out in @NatureMedicine : we show the opioid system modulates ketamine’s effects in major depressive disorder, with naltrexone pre‑treatment reducing acute glutamatergic activity and acute antidepressant effects. nature.com/articles/s4159…
Tenure-track faculty search of the @Ucsf_Biochem Department is open for applications! We are looking for creative, innovative scientists asking fundamental questions in any area of biology. Join our vibrant, collaborative, and supportive community! aprecruit.ucsf.edu/JPF05702
The Acute and Chronic Pharmacokinetics and Pharmacodynamics of Oral CBD With and Without Low Doses of Δ9-THC doi.org/10.1093/jat/bk…
CBD is good right? Errr maybe not... In this RCT, I gave high doses of THC 🌿 to people with schizophrenia. Pre-treatment with CBD did not reduce the effects... but doubled them! 🤯 Sometimes I'm not sure that science is for me 🤡.
CBD is good right? Errr maybe not... In this RCT, I gave high doses of THC 🌿 to people with schizophrenia. Pre-treatment with CBD did not reduce the effects... but doubled them! 🤯 Sometimes I'm not sure that science is for me 🤡.
Cortical Serotonin Type 2A Receptor Activation Shields Episodic-like Memories from Retroactive Interference in Rodents biorxiv.org/content/10.110…
MRGPRX2!! A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis: Cell cell.com/cell/fulltext/…
Yep
Some students can be ridiculously hypersecretive about their research (like concealing gene lists that are anyway in the public domain). Over time, they realize that not only nobody will steal their ideas, but that they'll be lucky if anybody is interested in them.
⚡️🧠A nociceptive amygdala-striatal pathway modulating affective-motivational pain Now published on the cover of @ScienceAdvances !!! Improved with projection-specific, pain-active intersectional chemogenetic pain behavior Check it out 👇 science.org/doi/10.1126/sc…
⚡️🧠A nociceptive amygdala-striatal pathway modulating affective-motivational pain Now published on the cover of @ScienceAdvances !!! Improved with projection-specific, pain-active intersectional chemogenetic pain behavior Check it out 👇 science.org/doi/10.1126/sc…
Nope this direct identification of interacting proteins via mass spec following in vivo proximity biotinylation en.m.wikipedia.org/wiki/Proximity…. My question was rhetorical, sorry my humor is not to clear.
Just wait until ‘psychedelic’ makes its way to breakfast cereal l
What's the optimal number of steps of physical activity that is associated with multiple (9) favorable outcomes? The largest, systematic review of 57 studies, 35 cohorts. 7,000 steps is clinically meaningful; some benefit also seen for 4,000 steps cf 2,000 steps @TheLancet…
Ok folks interested in #psychedelics and intracellular receptors: if these were the Gene-ontology results of an experiment would you say this was 'intracellular' or 'typical synaptic signaling'?
