sandynandagopal

Can we use RNA to insert kilobases of DNA into the human genome, opening up a new way to engineer cells or treat disease? Excited to share our latest work turning a retrotransposon (a “jumping gene” with an RNA intermediate) from songbirds into a genome editing tool. 🧵 (1/7)

In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out it’s both! Excited to share the 1st preprint from my postdoc w/ @SeanMegason @SeanEMcGeary @KleinLabHMS 1/20 doi.org/10.1101/2025.0…

We *know* this happens, but to actually see it is an entirely different thing. Amazing!

How does one (signaling) arm know what the other is doing in the cell? Through a network of bHLH transcription factors obviously! Our work showing how neural stem cells integrate signals to coordinate a fate response is now out: cell.com/cell-reports/f…

📢We are hiring! We’re looking for postdocs who are excited about uncovering mysteries of development using cutting edge spatial methods, including imaging based barcoding and spatial transcriptomics. If this is you, please reach out! [email protected]

How can we design protein-level circuits in cells by programming proteins and their interactions? @ElowitzLab and I attempt to establish design principles, highlight past work, and suggest future directions in this review: authors.elsevier.com/a/1cue7L7PXezoe

So thrilled to share our #CryoEM structure of the 56-subunit human #Mediator bound #Transcription PIC. Led by fearless @RyanAbdella and @anna_talyzina in a wonderful collaboration with the @TjianDarzacq group. science.sciencemag.org/content/early/…

TODAY IS THE DAY! I’m unbelievably excited to announce that today I start leading a group @Caltech to apply synthetic biology circuits for human therapies w/ @elowitzlab. And we are hiring. phf.tbe.taleo.net/phf03/ats/care…

NYC’s Street Trees "For the first time, you have access to information about every street tree in New York City" 🤩😍 tree-map.nycgovparks.org/tree-map

Please RT 🙂 ! The Tsai lab starts @WashUDevBio today! Interested in how cells integrate biochemical and mechanical signals to build patterns and fold tissues reproducibly in zebrafish? We are recruiting at all levels! #zebrafish #development #biophysics sites.wustl.edu/tsailab/