Zibo Chen
@ZiboChen
Assistant professor @westlake_uni. Protein design and synthetic biology. Pilot (PPL, IR).
LIDAR is out! rdcu.be/efugD We've improved a lot, e.g., making MESA-like LIDAR work, RNAseq of on-/off-target editing, and optimizing RNA delivery. We are one baby step closer to making it useful for therapeutics. NIH high-risk high-reward program provides key support.
Following our field's inspiring history of building synthetic receptors, here we share our lab's first attempt at a post-transcriptional one. Based on ADAR-editing and compatible with various inputs/outputs.
🚨NEW PUBLICATION ALERT🚨: In a paper out today in @ScienceMagazine we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/sc…. 🧵1/n
Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. biorxiv.org/content/10.110…
So well deserved!
Congratulations to HHMI Investigator David Baker who has won the 2024 @NobelPrize in Chemistry for his work on computational protein design! He shares the prize with Demis Hassabis and John M. Jumper for protein structure prediction. #NobelPrize hhmi.org/hhmi-david-bak…
In case it's helpful to anyone, I posted the evolving set of talk tips that I share with my lab on our website. Scroll to bottom of this page: elowitz.caltech.edu/teaching. (It was once "10 commandments" but has since expanded to 25...the slide titles are currently number 5)
Exciting news: AlphaFold 3 has been announced and will be published in 6 months.
We love the excitement & results from the community on AlphaFold 3 and are doubling the AF Server daily job limit to 20. Happy to also share that we're working on releasing the AF3 model (incl weights) for academic use, which doesn’t depend on our research infra, within 6 months.
A bit late to this, but thank you @DamonRunyon for the continued support, and @MoKhalilLab & @ElowitzLab for your generous letters!
👏 Congratulations to Prof. @ZiboChen at Westlake University on receiving the @DamonRunyon -Dale F. Frey Award for Breakthrough Scientists! 🏆🔬 His innovative research on protein-based molecular programming for cancer immunotherapy opens new possibilities for #cancer prevention,…
Love the Zelda reference
Happy and super excited to share our discovery of a protein fractal! We unravel the surprisingly simple emergence of these marvellous structures and show it might have even been an accident of evolution. Read the full story here nature.com/articles/s4158… Or just stick around 🧵
Our first paper is out in @CellCellPress! Led by @born2raisecell, we present a programmable reaction-diffusion system that generates synthetic protein waves, oscillations, and patterns for spatiotemporal circuit design and FM data-encoding in human cells. authors.elsevier.com/a/1iN8ZL7PXmeeN
Can the intrinsic physics of multicomponent systems show neural network like computation? Out now: nature.com/articles/s4158… Led by Constantine Evans w/ Jackson O'Brien, Erik Winfree. U Chicago summary: news.uchicago.edu/story/uchicago…
Excited to share that I'll be starting a group @ETH_BSSE researching at the intersection of protein design, biology and AI. Come join us! x.com/ETH_en/status/…
On the proposal of ETH Zurich President @Joel_Mesot , the ETH Board appointed 12 professors and awarded the title "Professor of Practice" once. 👨🏫👩🏫 brnw.ch/21wF6YH @MortezaAramesh @ellliottt
It has been exactly one year! Cannot thank these amazing folks enough. Here is to another year of fun doing science and hopefully many more 🍺
