Grace Edmonds

Can we use RNA to insert kilobases of DNA into the human genome, opening up a new way to engineer cells or treat disease? Excited to share our latest work turning a retrotransposon (a “jumping gene” with an RNA intermediate) from songbirds into a genome editing tool. 🧵 (1/7)

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput method to measure nuclear condensate formation & applied it to ~14000 IDPs to find out rdcu.be/eq975

In the latest issue! Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins dlvr.it/TK21Y8

The amount of bizarre political advertisements on my feed is getting out of hand 😳 is it finally time to swap platforms? I am kedmonds.bsky.social, I’ll try to re-add people there too (this feels like getting a new phone in the 2000s).

The Kappel Lab is opening soon at UCLA and we’re hiring Staff Scientists to help lead our wet-lab projects & to assist with lab management! We have open positions for candidates with a PhD & for recent college grads. Learn more and apply: forms.gle/76inzTL6FoTcRP… Please RT!

How does one (signaling) arm know what the other is doing in the cell? Through a network of bHLH transcription factors obviously! Our work showing how neural stem cells integrate signals to coordinate a fate response is now out: cell.com/cell-reports/f…

Check out our new review of molecular recording, exploring cutting-edge technologies and their transformative potential for biology. A collaborative effort across multiple labs—proud to have been part of this amazing team! 🌟

A dream come true: in 2004 I started thinking about counting microstates to predict gene expression with @JKondev Rob Phillips @HernanGGarcia. 20 years later we can measure them: nature.com/articles/s4158… Thank you @WJGreenleaf @bgrdoughty @MichaelaThinks Julia and all co-authors!

In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! biorxiv.org/content/10.110…

What if you could find out the history of signaling activity in each cell with a single round of imaging? Wouldn't that be incredible? Well, we thought so too. And that's what we set out to achieve with INSCRIBE in our new preprint. Let’s dive in! 🚀🔬 biorxiv.org/content/10.110…

Our paper on continuous mutagenesis in living cells using HACE is now out in @ScienceMagazine! We now demonstrate that HACE continuously generates mutations over a 10-day period and enables targeting using dCas9 without introducing DNA nicks. science.org/doi/10.1126/sc…

Friends, if you’re looking for an absolutely fantastic mentor and fascinating research…

So excited to announce that the Kappel Lab will open at @UCLA @uclachem in July 2025! We’ll combine high-throughput experiments and computation to build predictive sequence-structure-function models of RNA, proteins, and their interactions. More here: sites.google.com/view/kappellab/

Check out this trippy and creative defense system