Mathew Barber

The 5 biology papers & areas of progress I found most impressive in 2024 (with video explainers for each!): 1/n

Very excited about this paper. Tweetorial coming soon!

Our AI for virtual cells article is now published in @CellCellPress with lots of amazing co-authors who gathered with us at @cziscience and @_bunnech, Aviv, @Prof_Lundberg , @jure , and @StephenQuake sciencedirect.com/science/articl…

Introducing a new method called REMETA from the Regeneron Genetics Center (RGC) @RegeneronDNA for meta-analysis of gene-based tests using summary statistics rgcgithub.github.io/remeta/ This is great work from Tyler Joseph. Pre-print is here​ medrxiv.org/content/10.110…

Analysis of sequencing data of 320k individuals (75k cases and 245k controls) shows heterozygous carriers of cystic fibrosis mutations are protected from inflammatory bowel disease. The protection mechanism could be due to an altered gut mucosal barrier that resists penetration…

The (true) story of development and inspiration behind the "attention" operator, the one in "Attention is All you Need" that introduced the Transformer. From personal email correspondence with the author @DBahdanau ~2 years ago, published here and now (with permission) following…

I recently wrote a primer on UMAP for Nature Reviews Primers. If you are looking for an overview of the method, a getting started primer, or best practices it is a good place to start. rdcu.be/d0YZT

Our new textbook Theoretical Foundations of Conformal Prediction is out! Conformal prediction is a a statistical technique that augments ML systems with uncertainty information for safe deployment. This book lays out the core theory. arxiv.org/abs/2411.11824

🚨 New Textbook on Conformal Prediction 🚨 arxiv.org/abs/2411.11824 “The goal of this book is to teach the reader about the fundamental technical arguments that arise when researching conformal prediction and related questions in distribution-free inference. Many of these…

Today we report Evo, a generalist foundation model for biology, on the cover of @ScienceMagazine. Trained on billions of DNA nucleotides, Evo was designed to capture two key aspects of biology: the multi-modality of the central dogma and the multi-scale nature of evolution.

Maybe everyone already knew about this, but the @AllofUsResearch results browser is up so you can look up your favorite genetic associations (I assume this is the browser @konradjk presented at #ASHG24 that is now ready?). allbyall.researchallofus.org

Yesterday was a hard day at 23andMe, and we said goodbye to a number of tremendously talented colleagues. If people have job openings in the genetics space that they'd like me to share with the impacted folks, please do post here.

"I spent too much time on QC to not have a slide about it" 😂☺️ #ASHG24

We have an exciting new opportunity to join the data science team at Inscripta! We are working on many exciting projects using deep learning with high-content imaging and gene editing to help shape the future of synthetic biology. Pls RT recruiting.paylocity.com/Recruiting/Job…

Data preparation! It's crucial for machine learning, and we all hate it. Tools and techniques to reduce this burden? A quick summary of 10 years of R&D on this, from cheap tricks to LLMs and graph neural networks 1/9

After testing in our lab, we validated that 5 of those proteins actually show binding affinity to EGFR. That's 5 completely novel proteins that don't exist in nature or scientific literature and have passed the first validation to potentially become new cancer drugs. To put this…

I'm looking to change my career path and am quite excited about exploring jobs in biotechs in the Bay Area (or remote). I'm very keen to start a career that offers stability so my partner and I can finally live in the same state. Does anyone know of organizations that are hiring?

Nobel Laureate David Baker on the phone with fellow awardees Demis Hassabis and John Jumper. The trio discussed how their teams have inspired one another and what the future may hold.

The first episode of @BakerLabPodcast is live. Meet Mohamad Abedi, who went from being a Palestinian refugee to a postdoctoral researcher. His journey proves that science can be a creative and transformative process. Apple: podcasts.apple.com/us/podcast/the… Spotify: open.spotify.com/show/32pWWpKzO…

So this plagiarism thing has happened to our lab.. again. This time it's plagiarism of our poseidon syringe pump paper @booeshaghi et al., 2019 in @SciReports: nature.com/articles/s4159… Text has been plagiarized, as well as figures copied directly here: ijirset.com/upload/2024/ma… 1/🧵