Jack Kosmicki
@jakphd
Statistical geneticist @ Regeneron | PhD @broadinstitute & @harvardmed | tweets are my own | he/him/his
It's funny how people think they can just assert the linear model doesn't work without any argument or evidence like no one has ever thought of this before or looked into it.
I don’t know who needs to hear this, but GWAS is a totally inappropriate basis for embryo editing. It is fundamentally a linear model. Few things in the universe are as nonlinear as genotype-to-phenotype. Every allele must be causally validated via experiment.
This made my weekend 🤣🤣🤣
I heard on LinkedIn that this was an insider joke at 23andme research team. They used the acronym TTAM in their slides and one day, Anne noticed it and asked "What does TTAM mean in your slides?" 😂 linkedin.com/posts/bpanahi_…
Amgen trial one shot a month but 24% instances of vomiting to start. Way too high versus once a week LLY. LLY coming out with one pill a day no side effects to speak of, versus once a month injectable. with diminished vomiting or even once a quarter injection and people still…
Today, we are thrilled to announce that @VerveTx has entered into a definitive agreement to be acquired by @EliLillyandCo From 2018 to 2025, Verve moved a new concept (a one-dose future for the treatment of atherosclerotic cardiovascular disease) and a new medical technology (in…
Heartbroken to share my mentor & friend Dr. Atul J. Butte @atulbutte has passed. He saw potential in me and turned it into opportunity-- for me, and so many others. We bonded over Star Trek and he was our Captain. Picard’s parting toast in his honor, final episode:…
In the latest update to the 23andMe, Anne Wojcicki (i.e., not $REGN) won the bidding war. wsj.com/tech/biotech/a…
I clearly celebrated far too soon 😥
I guess my 23andMe lunch bag was "on brand" the entire time 😂
Year ago, the prevailing attitude was that deep learning would significantly improve polygenic risk scores (or anything else, to be fair). A rather important set of negative results indicating that isn't the case (though I imagine many will still try). nature.com/articles/s4146…
Whelp, the sale was premature. Former CEO, Anne Wojcicki, reopened the 23andMe auction with a new $305 million bid. bloomberg.com/news/articles/…
🤯 Wow, $REGN bought 23andMe for $256 million. cnn.com/2025/05/19/bus…
Congrats to everyone involved in the long COVID GWAS - diligence and perseverance paid off with an association near FOXP4 that increases risk (OR=1.63; P=1.76e-10). nature.com/articles/s4158…
🤯 Wow, $REGN bought 23andMe for $256 million. cnn.com/2025/05/19/bus…
🤯Wow, Kári Stefánsson stepped down from deCODE - end of an era. ruv.is/english/2025-0…
Carl Sagan was really ahead of his time. Absolutely prescient quote from one of his final interviews.
It's incredible how far we have come from saturated mutagenesis of 1 gene (BRCA) in 2018 to now 500 protein domains. bsky.app/profile/jakphd…
This is the most Boston thing I have seen in a long time 😆😆😆
It's the 250th anniversary of the midnight ride of Paul Revere. I've mapped all seven Dunkin Donuts locations Paul could've stopped at on his route