Lior Pachter
@lpachter
Bren Professor of Computational Biology @caltech. Blog at http://liorpachter.wordpress.com. Tweets represent my views, not my employer's. #methodsmatter
This is a good article and I agree with its argument for comprehensible research.
How can we reform science? I have some ideas. But I am not sure you’ll like them, because they don’t promise much. elevanth.org/blog/2025/07/0…
Given incredibly difficult, conflict-filled years,it makes me proud to present @BZman101 beautiful work on intra-host evolution in SARS-CoV-2. Briefly,we find evolution differs among patients: in some nothing happens; in others rampant adaptive evolution. academic.oup.com/ve/article/doi…
I recently learned of the Damm algorithm which is very cool. en.wikipedia.org/wiki/Damm_algo…
Sina's recorded defense is an awesome resource for those interested: youtube.com/watch?v=xD-lZG…. He came into the space with a MechE background and questioned engineering assumptions + vendor prices with single cell tooling
LR-Kallisto spotted!
Dogme: A nextflow pipeline for reprocessing nanopore RNA and DNA modifications pubmed.ncbi.nlm.nih.gov/40501581/ 🧬🖥️🧪 github.com/mortazavilab/d…
aka PCA
Most tech people know about ordinary least-squares (OLS), but not so much about *total* least-squares (TLS) They measure fit differently: OLS minimizes sum of sq. distances along dependent variable; whereas TLS minimizes sum of orthogonal distances from data to fit line 1/2
The confiscation of cell phones from children at schools & summer camps is largely the result of a national campaign by @JonHaidt. But cell phones are safety devices used for notification & early warnings of active shooters, earthquakes, floods, tornados, tsunamis, wildfires, ..
