Marco Osterwalder
@m_osterwalder
Cardiac development and functional genomics @DBMR_UniBe
How do enhancers work over distances that sometimes exceed megabases? Excited to share our work led by @gracecbower where we uncover a unique sequence signature globally associated with long-range enhancer-promoter interactions in developing limb buds: biorxiv.org/content/10.110… 1/
Updated VISTA Enhancer Browser, 7 years in the making, out in @NAR_Open! >4,500 transgenic in vivo enhancer experiments for all your developmental biology, human variation and #evodevo needs. enhancer.lbl.gov #enhancers #embryos doi.org/10.1093/nar/gk…
🧬 Forschende des @DBMR_UniBe, @MedFacultyUniBE und der @inselgruppe haben gemeinsam mit @UCalgary und @BerkeleyLab in einer "Genwüste" 🏜️ wichtige Steuerungselemente für die Embryonal- und Herzentwicklung identifiziert: sohub.io/z647.
🎉Excited to finally share that our new work (previously @biorxivpreprint) is now online at @Nature! A fantastic team effort with amazing collaborators. You can read the paper by using the following link: rdcu.be/dXQs7 A thread 🧵/1 nature.com/articles/s4158…
The Kvon lab is hiring a postdoc. We developed lots of powerful in vivo tools to address exciting questions in gene regulation, congenital disorders and evo-devo. We are located in sunny Southern California close to the ocean. Email me if interested. kvonlab.org
Beta-version of the new VISTA Enhancer Browser, 7 years in the making, with support for developmental stages, different species and variant comparison is finally online. Feedback is welcome! vista-enhancer.lbl.gov #enhancers #embryos #evodevo
The revised version of our chondrogenic enhancer preprint is out today, featuring the in vivo assessment of enhancer deletions at Fgfr3, Col2a1, Hhip, and Nkx3-2. nature.com/articles/s4146…
Our new preprint with @F_Darbellay exploring the transcriptional control of chondrogenic and late-acting patterning genes during cartilage formation. tinyurl.com/2p8ffukw Huge thanks to @AxelVisel, @michaelkosicki, @AnnaRamisch, #LDelisle #chondrocytes #enhancers 1/8
Nice correlation between massively parallel reporter assays (MPRAs) and mouse enhancer assays and great neurodev enhancer catalog. Great work and collaboration from @michaelkosicki, @DianneLaboy, @LenPennacchio and many others. biorxiv.org/content/10.110…
I am extremely happy to share with you today my latest work now in #bioRxiv at @guillaumeandrey lab. Don't miss it if you want to know how temporal constraints on enhancer usage shape the regulation of limb gene transcription! biorxiv.org/content/10.110…
Our #preprint on gene regulatory trajectories with @Raquel_Rouco is out! We find that different enhancer repertoires act transiently and subsequently to sustain cognate gene expression over time. And more on E-P interactions and digit formation! 1/X biorxiv.org/cgi/content/sh…
Our preprint characterizing mouse developmental Enhancer—Promoter interactions by @Czx17943830 is out today @NatureGenet rdcu.be/dBRPu See also a complementary study on fly Enhancer—Promoter interactions from @Eileen_Furlong nature.com/articles/s4158…
How important is Enhancer—Promoter physical proximity for developmental gene activation? Happy to share our work led by postdoc Zhuoxin Chen @Czx17943830 where we systematically address this question in vivo. (1/n) biorxiv.org/content/10.110…
New preprint from the lab! Led by Irfan Kathiriya, we discovered that a sublineage of cardiac precursors is a compartment boundary required for interventricular septation, regulated by TBX5, which controls its integrity, and Slit2 and Netrin1 signaling biorxiv.org/content/10.110… 1/x
Bonkers paper! From TF cooperatively and interdependence to crystal structure to biochemistry to human genetics! Tour de force from Joanna Wysocka's team including @seungsookim10, @jussitai, @snaqvi1990, and others: cell.com/cell/fulltext/…
🚨we’re looking for a Postdoc (2-years initially) to develop a project on dev. tempo in mouse embryos 🐭 ⌛️ 📩 drop an email for further info Link: babrahaminstitute.livevacancies.co.uk/#/job/details/… Closes Jan 31st 🔁Please RT
We are very excited to present a major breakthrough achievement – the de novo design of synthetic enhancers for selected tissues in fruit fly embryos in vivo using deep- and transfer learning, @deAlmeida_BPet al published today in @Nature nature.com/articles/s4158…. Thread 👇(1/N)
How to test the functional impact of noncoding variants in vivo? Happy to share our work led by @ewholling where we developed dual-enSERT, a new method that enables rapid, quantitative comparison of human enhancer variant activities in live mice. Check this Tweetorial for details
Much of human disease-linked variation maps to regulatory regions. Yet, our ability to test the effects of these noncoding variants remains limited. In our new @biorxiv preprint, we asked if we could begin to chip away at this bottleneck: biorxiv.org/content/10.110… 1/
Our multi-chamber cardioid paper is finally out! Big thanks to the whole team & collaborators, #IMBA for their continuous support, and the reviewers & editors for facilitating further improvements. Thank you!
Now online! Multi-chamber cardioids unravel human heart development and cardiac defects dlvr.it/SzRL7b
The EMBO workshop on #limbdevelopment #regeneration #evolution #congenital and #disease happens in Dresden June 2024 #limb_24. Great program and speakers - register and submit abstracts now. 25 additional speaker will be selected from applicants. Dresden -the place to be:
Now online! Multi-chamber cardioids unravel human heart development and cardiac defects dlvr.it/SzRL7b