Ethan Hollingsworth
@ewholling
MD/PhD Student in the Kvon Lab @UCIrvine | Gene regulation in development and disease
How do non-coding variants in enhancers cause human disease? Here, in my main PhD work with @evgenykvon, we uncover a surprising mechanism, with generalizable implications for human genomics. tinyurl.com/89tdkevu n/
Awesome to see this story from our lab finally out! Shoutout to @gracecbower for making 4 new mouse lines just for revision experiments 🤯
Our preprint describing the Range Extender element, which is required and sufficient for long-range enhancer activation at the Shh locus, is out in @Nature. nature.com/articles/s4158…
Plasmid-based reporter assays are the bedrock of regulatory genomics. But a basic question has gone unanswered for decades: Do chromatin architectures form on plasmids transfected into mammalian cells—and does it matter? We finally have answers. biorxiv.org/content/10.110…
At 15, I left all my family and friends and came to the US , ALONE, seeking a country where MERIT and HARD WORK mattered-not politics. For 30 years, I worked tirelessly, even doing reseach at MIT the day my mother died, knowing she’d want me to keep pushing forward. Today, my…
The first story of my PhD out now in final published form, including new untested variants (see below)!
Our preprint is out nature.com/articles/s4146… In a new set of experiments, we screened a panel of rare and common variants from patients with Autism and identified variants in enhancers of OTX2 & Mir9-2 that reproducibly alter their activity in vivo! Huge congrats to @ewholling