Michael Alexanian
@m_alexanian
Assistant Professor @GladstoneInst @UCSF studying Cardiovascular Epigenomics. Theater teacher @UCSF_Improv http://michaelalexanianlab.com
🎉Excited to finally share that our new work (previously @biorxivpreprint) is now online at @Nature! A fantastic team effort with amazing collaborators. You can read the paper by using the following link: rdcu.be/dXQs7 A thread 🧵/1 nature.com/articles/s4158…
I am saying goodbye as an active member of X (but find me in @drusqui.bsky.social) with our exciting new paper @Nature. The fruit of massive work by @TVicanolo, @alazozcan and Jackson Li, and our superb collaborators @lai9uan and @red_ven. True teamwork! nature.com/articles/s4158…
3 weeks into the new editorial board for JACC BTS, the JACC family member for basic and translational discoveries! Please consider JACC BTS for your manuscripts. We do fast, friendly and fair peer review. Because life is short and science is fast ⚡️❤️🔥🧠
BCVS 2025-Join global experts for breakthrough cardiovascular research, and professional growth July 23–26, 2025 | Baltimore, MD @DrHelenECollin1 @AHAScience @mkontari @VagnozziRJ @AndrewGibbPhD @karchoptosis @Jess4genes @BCVSearlyCareer professional.heart.org/en/meetings/ba…
Why is the T-box TF Eomes required for embryo implantation and development of the trophectoderm lineage? We are happy to share our work about the molecular role of Eomes in trophectoderm development rdcu.be/eo3zu
Maarten van den Hoogenhof found a specific way to improve cardiac function in RBM20 cardiomyopathy. CAMK2 inhibition might become the first tailored therapy for a Dilated Cardiomyopathy (after mavacamten for Hypertrophic Cardiomyopathy): biorxiv.org/content/10.110…
Thrilled to share our latest preprint led by the fantastic student Ziyu @ziyu__lu! We constructed a scATAC-seq atlas profiling > 500 mouse tissues to explore cell population dynamics during mammalian aging and the associated chromatin landscape changes: biorxiv.org/content/10.110…
🚨Preprint alert!🚨 Why do high-altitude populations have lower rates of metabolic syndrome and lower blood glucose? Superstar postdoc Yolanda tackled this❓tinyurl.com/2x7ptyn8 @GladstoneInst @arcinstitute @UCSF #hypoxia #oxygen
Our first foray into using AI to tackle human cardiac fibrosis. ahajournals.org/doi/full/10.11…. Amazing collaboration with @gwaybio and waysciencelab.com. Spearheaded by @JoshTravers89 and @jenna_tomkinson. Tip of the iceberg. Stay tuned!
CHOIR is now online @NatureGenet! CHOIR is a new clustering method for single-cell data that evaluates whether clusters represent statistically distinct cell populations. CHOIR scales to millions of cells and works with single-/multi-omic data of any type! nature.com/articles/s4158…
Still buzzing from this show — what a night! So lucky to share the stage with such a brilliant, hilarious crew. Thanks to everyone who came out! 💥🎭
Our #improv show last Friday @TheLostChurchSF was an absolute blast! Huge thanks to everyone who came out — such an electric crowd. Loved every moment. 🎭🔥
our work on the molecular differences between transcription factor isoforms is out now in @MolecularCell! key point: 2/3rds of TF isos differ in important properties like DNA binding & transcriptional activity many are "negative regulators" that are misexpressed in cancer
Can confirm: this is going to be a blast 😄🧪🎭 Come see us #scientists do #improv this Friday March 28 at @TheLostChurchSF!
🎭 This Friday, March 28, our #UCSF #improv group is hitting the stage at @TheLostChurchSF! A bunch of #scientists doing improv—what could go wrong? (Or very right 😄) Expect laughs, chaos, and a great show! 🎟️ Grab your tickets here: thelostchurch.my.salesforce-sites.com/ticket/patront…
🎭 This Friday, March 28, our #UCSF #improv group is hitting the stage at @TheLostChurchSF! A bunch of #scientists doing improv—what could go wrong? (Or very right 😄) Expect laughs, chaos, and a great show! 🎟️ Grab your tickets here: thelostchurch.my.salesforce-sites.com/ticket/patront…
Our paper plus the cover in @CellSystemsCP on cardiac fibrosis. A novel insight on these pathologies with some therapeutic solutions.
Our work made it to the cover of @CellSystemsCP! 🥳 Cold and hot fibrosis define clinically distinct cardiac pathologies Check out our paper here: cell.com/cell-systems/f… @UriAlonWeizmann @Tzahore @MiriAdler @WeizmannScience @HebrewU
The Moslehi laboratory is recruiting a post-doctoral fellow with a PhD in immunology or molecular biology. See below! nature.com/naturecareers/… Below information about the lab: cardiooncologylab.ucsf.edu Interested candidates can email me with CV! [email protected]
4 y ago, we showed that boosting NAD+ treats exp. HFpEF. Now, I am thrilled to share our @ehj_ed paper, where we reveal this relies on autophagy activation via reduced IGF1 signaling (not deacetylation!) and translational relevance in a prospective cohort! academic.oup.com/eurheartj/adva…
Ada is already a superstar and we are so lucky to have her in our team!
Meet Ada Zhu, a research associate in the Alexanian Lab (@m_alexanian), whose passion for heart disease research is driven by personal experience and fueled by Gladstone’s collaborative community. bit.ly/41wJvBJ
for #heart month, a nice piece on what we at @GladstoneInst are doing to understand heart disease better. Featuring @m_alexanian @TheodorisLab and Katie Pollard. for heart month, a nice little piece on what we do at Gladstone for the heart gladstone.org/news/matters-h…
Researchers at Gladstone develop a drug that mimics the cellular effects of low-oxygen therapy for the treatment of inherited mitochondrial diseases. @ishahjain @CellCellPress @arcinstitute @UCSF @MazeInBiotech @NIH @CDMRP gladstone.org/news/daily-dru…
Super excited to share that our manuscript is finally OUT @CellSystems!!🚨 Cold and hot fibrosis define clinically distinct cardiac pathologies. cell.com/cell-systems/f…🧵(1/)