Joe Bondy-Denomy
@joeBondyDenomy
Associate Prof. @UCSF, Dept. of Micro & Imm. Toronto and Waterloo alum. Acrigen Biosciences co-founder. he/him/his
Late-decision abstract submissions are open for Phage Biology, Dynamics, and Therapeutics: iasusa.org/bacteriophage-…
How do bacterial extracellular Contractile Injection Systems bind target cells? A remarkable diversity of receptor binding domains biorxiv.org/content/10.110… #biorxiv_micrbio
Check out our new paper describing rAcrVIA1: an RNA anti-CRISPR that mimics guide RNAs to inhibit Cas13. Very fun project with stellar UW undergrad Victoria Hayes and collaboration with Ning Jia's group! science.org/doi/10.1126/sc…
In @nature we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR-Cas9 enzymes, offering safer & more genome editing tools. 🧬🖥️ @RachelSilvers11 @CGM_MGH @MGH_RI @MassGeneralNews @harvardmed nature.com/articles/s4158…
The lab is now up and running at New England Biolabs @NEBiolabs! I'm looking for a postdoc to study phage defence systems. If you'd like the academic freedom to publish but the resources of industry, then take a look 🤓😃 neb.wd5.myworkdayjobs.com/en-US/NEB_Care…
Check it out! Favorite model organism? see what gene(s) you should work on. Favorite gene(s)? See what model organism you should use!
Zoogle! Our new tool from @arcadiascience for picking research organisms. Even if you’re not a scientist, you should care that we spend >$50B/yr on clinical trials based on organismal models (>90% failure rate). Read more about Zoogle here: arcadiascience.com/blog/zoogle
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis…
📢Excited to introduce NanoCas -our new mini CRISPR system that can reach tissues previously out of reach! By shrinking CRISPR to 1/3 its normal size, we can now edit genes in muscle, heart & brain that were difficult to access before. Summary & link to paper:
Apply now, spread the word: three (3) fully funded Helmholtz research groups (assistant prof level) with attractive packages. Topics: RNA-based medicine, microbial RNA, and RNA-based infection research incl. RNA technologies. Great environment for young people. Come and join us.
Is it “winner-takes all” when the simplest living things compete? Check out my fresh publication on phage coexistence in Science and a thread below🧵 science.org/doi/10.1126/sc…
🧬 Big Pharma's antibiotic problem: A successful drug + FDA approval = $776M loss Here's how that happens 🧵
New CDN binding domain!
ComFB, found in bacilli, clostridia, cyanobacteria, spirochetes, beta-, gamma-, and the former deltaproteobacteria, is a widespread c-di-GMP (and also c-di-AMP) receptor protein. biorxiv.org/content/10.110…