Tim Blower
@BlowerLab
Senior Principal Investigator at New England Biolabs and Honorary Professor at Durham University. Views my own. He/him.
For those of you who approached me at @MicrobioSoc #Microbio25 (and anyone else interested!!), this is your last chance to apply for our PDRA position. Come join us in Glasgow!
🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now ! tinyurl.com/bddz4z44
Super opportunity to join Giusy in Glasgow!
🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now ! tinyurl.com/bddz4z44
The final version of our Serratia paper is now out! Congrats to @TomCX99 and (X-less) Suraj, and a big thank you to @BlowerLab and @StephenRG97. tinyurl.com/3vnyvufa
New pre-print from the lab, led from (for now Twitter-less) star-RA Tom Cummins. If you did receive his PhD application, you do not want to miss this chance, Tom is a star! As always, fun collaboration with the amazing @BlowerLab and @StephenRG97
Over the moon to share some amazing news—I’ve been awarded an MRC Career Development Award to pursue my research at the University of Glasgow @UofGSii ! 🎉 Can’t wait to get started on this exciting new chapter. Stay tuned—I’ll soon be advertising a PDRA position!
When experiments don’t work... build a phage costume! 🎃 Happy PHAGEOWEEN!!! 👻🧬#Teamwork
RptR is a new addition to the growing collection of phage defence-associated transcriptional regulators. Congrats to @YugengZ @TangLabOxford @_MarionSchuller @IvanAhelLab and thank you, it was a pleasure to help out the study! @NEBiolabs. academic.oup.com/nar/article/53…
Latest BREX story from the lab - turns out there is a nuclease after all! Congrats to Jenny Readshaw and the whole team, including wonderful collabs Barry Stoddard, Brett Kaiser and @DarrenSmithdx. @NAR_Open @NEBiolabs @DurBiol academic.oup.com/nar/article/53…
We are delighted to host Professor Tim Blower @BlowerLab as keynote speaker to our MID symposium @WarwickLifeSci Date: 20th of June Venue: GLT1 We invite MBio, PhD students and Postdocs to submit abstracts for posters and talks by 11th of June to @CRodriguesLab
Using cryoEM we understood the structural basis of chiral DNA wrap by bacterial gyrase (and also produced the most complete/highest resolution E coli gyrase model to date). @JohnInnesCentre @DurhamU34989 @MCB_UJ
Thrilled to share my latest postdoc paper published in @NatureComms NTase toxin targeting serine tRNA 3'-ends by CMP addition in M. tuberculosis H37Rv. Thanks to all the co-authors, @GenevauxPierre @BlowerLab @ONeyrolles rdcu.be/dZle4
journals.asm.org/doi/10.1128/jv… Our thoughts on how toxins bound to TAs are activated: via conformation changes, not by selective degradation of ATs by a protease (makes little sense since both are structured). Remarkable insights determined by studying various TAs as they inhibit phage.
Researchers @blowerlab and colleagues use biochemistry, biophysics, and crystallography to characterize a mechanism of antitoxin induced autophosphorylation that can neutralize nucleotidyltransferase toxins of Mycobacterium tuberculosis nature.com/articles/s4146…
Congratulations to @BlowerLab and @tomarrow234 Happy to be involved in this wonderful collaboration! NTase toxins are truly amazing! Dissecting the antitoxin-mediated Toxin auto-phosphorylation rdcu.be/dSXxi
My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/