Isha Jain
@ishahjain
Core Investigator @arcinstitute & Associate Professor @Gladstone @UCSF studying the mysteries of oxygen, vitamins and aging
🚨Preprint alert!🚨 Why do high-altitude populations have lower rates of metabolic syndrome and lower blood glucose? Superstar postdoc Yolanda tackled this❓tinyurl.com/2x7ptyn8 @GladstoneInst @arcinstitute @UCSF #hypoxia #oxygen
A great line-up of speakers for Cell Symposia Multifaceted Mitochondria June 2026 in Glasglow! Check it out and register early: cell-symposia.com/mitochondria-2… @KivancBirsoy @RutterLab @jourdainlab and more! #mitochondria @CellPressNews
Beyond excited to share our #NewPaper in @CellCellPress! Inflamed environments acidify intracellular pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of inflammation. #inflammation #pH authors.elsevier.com/sd/article/S00…
I can’t get this line out of my head since reading it at the end of the abstract for this paper: “Sleep, like aging, may be an inescapable consequence of aerobic metabolism.” nature.com/articles/s4158…
Online Now: An NADH-controlled gatekeeper of ATP synthase dlvr.it/TLbSJS
Delighted to announce @arcinstitute's Virtual Cell Challenge - a recurring, open, community-driven challenge to benchmark cellular foundation models See our announcement in @CellCellPress below, with prizes up to $100,000, sponsored by @Nvidia @10xGenomics @UltimaGenomics!
Register today for the Virtual Cell Challenge and use AI to solve one of biology’s most complex problems. Announced in @CellCellPress, the competition is hosted by Arc Institute and sponsored by @nvidia, @10xGenomics, and @UltimaGenomics.
Announcing the inaugural Virtual Cell Challenge! Hosted by Arc Institute, and sponsored by Nvidia, 10x, and Ultima, help solve one of biology’s biggest challenges with AI by building cell state models that accurately predict responses to perturbation. virtualcellchallenge.org
Register today for the Virtual Cell Challenge and use AI to solve one of biology’s most complex problems. Announced in @CellCellPress, the competition is hosted by Arc Institute and sponsored by @nvidia, @10xGenomics, and @UltimaGenomics.
We are deeply saddened by the passing of Dr. Atul Butte, a visionary scientist, educator and leader whose work reshaped biomedical research and health care. We extend our heartfelt condolences to Dr. Butte’s family, colleagues, trainees and collaborators. ucsfh.org/4n25xVH
Very proud of the hard work and resilience by @EdreesRashan, @AbbyBartlett_ and many others on this work!
As promised, a 🧵 on our recent article now out in @NatureSMB! Co-led with @AbbyBartlett_ @Pagliarini_Lab @JudithSimcox, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯#lipidtime doi.org/10.1038/s41594…
Today @arcinstitute releases State, our first perturbation prediction AI model and an important step towards our goal of a virtual cell State is designed to learn how to shift cells between states (e.g. “diseased” to “healthy”) using drugs, cytokines, or genetic perturbations
Preprint drop from our team at @arcinstitute! Introducing STATE: a model that learns and predicts transcriptomic responses to chemical or genetic perturbations. This is the first model to beat simple linear baselines and our first step toward building a virtual cell model.
Introducing Arc Institute’s first virtual cell model: STATE
Congrats @JaviGBermudez lab on this fantastic discovery! So well deserved!!! This needs to be considered for future ferroptosis work in vivo.
My lab's first paper is out in @Nature. We show that lipoprotein uptake protects tumors from ferroptosis by delivering the lipid antioxidant α-tocopherol. Surprisingly, tumors use sulfated glycosaminoglycans—not canonical receptors—to capture lipoproteins. nature.com/articles/s4158…
We're hiring a CSO to lead our institute initiatives!
Arc is hiring a Chief Scientific Officer! Come work with at what I think is the most dynamic and ambitious biology research organization in the world, partnering with @pdhsu, @SKonermann, @davey_burke, Arc's extraordinary faculty, and many more. We want to build the world's…
Come work with us at @arcinstitute
Arc is hiring a Chief Scientific Officer! Come work with at what I think is the most dynamic and ambitious biology research organization in the world, partnering with @pdhsu, @SKonermann, @davey_burke, Arc's extraordinary faculty, and many more. We want to build the world's…
Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases In new @arcinstitute work, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement
What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
We are excited to announce our 2025 @UofUDMRC Postdoctoral Rising Stars in Metabolism Symposium! This is truly a unique opportunity to network, present your research, and enjoy the breathtaking views that Salt Lake City has to offer. Deadline is May 15th, 2025. Please share!
The Sable Award lecture at METPHYS2025 was really remarkable! Tremendous congratulations to this years exceptional member of our community @KivancBirsoy
Check out our latest preprint, led by @schen_sc, that brings together an amazing team of scientists from several labs to tackle a fundamental problem in biology: how do cells regulate expression of their tRNAs? biorxiv.org/content/10.110…
Several groups have reported that prolonged high-altitude exposure lowers blood glucose. But the mechanisms have been unclear. Yolanda performed elegant experiments showing that expansion of red blood cells in hypoxia is largely responsible for this improved glucose tolerance!
🚨Preprint alert!🚨 Why do high-altitude populations have lower rates of metabolic syndrome and lower blood glucose? Superstar postdoc Yolanda tackled this❓tinyurl.com/2x7ptyn8 @GladstoneInst @arcinstitute @UCSF #hypoxia #oxygen
Our latest work, led by @__btjackson and Angela Montero @MSKCancerCenter demonstrates how intracellular metabolic gradients induce dependence on exogenous pyruvate in embryonic stem cells