Patrick Hsu
@pdhsu
co-founder @ArcInstitute, @BerkeleyBioE professor | researcher & investor in genome editing, biotech, AI | 🇨🇦 @harvard @broadinstitute @editasmed, Fast Grants
What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
The top three models for our Virtual Cell Challenge will win prizes valued at $100,000, $50,000, and $25,000. How can you get started?
Dropped the Virtual Cell Challenge Primer on HF. We are shipping transformers support for STATE (the SOTA model for predicting perturbation response) very soon!
incredible chess
am i hallucinating or did we just go from "openai acquiring windsurf" to "cog+ws team shipping wave 11" in seven days
the American deli sandwich must be the highest variance dish on the planet. sometimes it is nectar from the gods, other times a soul-sapping abomination
thinking in front of a screen restricts you to 2D thinking. it’s useful for reading, writing, coding, and spreadsheets that’s why the best thoughts are in the car, shower, or long walks
I think most people think better on a walk outside instead of staring at a computer screen at their desk. If you're not going on walks (and using AI voice dictation) to think you're missing out.
An absolute superstar @yusufroohani
Following the amazing talk today by Emma Dann we are excited to host @yusufroohani of the @arcinstitute for a special seminar this Thursday @ 10AM, presenting the efforts towards a virtual cell platform🔮
Delighted to back the @Nudge team (@FEhrsam, Jeremy Barenholtz, @quintinfrerichs) and their daring mission to improve brain health via non-invasive ultrasound neuromodulation with a consumer-grade product World-class science & engineering ⚔️ addiction, pain, sleep...
Half the world will experience a brain disorder in their lifetime. At @nudge, we're building brain interfaces that are safe, precise, and non-invasive to solve that problem. We've raised a $100M Series A led by @ThriveCapital and Greenoaks to go faster. We're hiring. Join us.
even Munger wanted longer context windows 1B token context wen?
Sage advice from Munger:
I heard reinforcement learning only works with verifiable rewards? 😛 Congrats!!
1/N I’m excited to share that our latest @OpenAI experimental reasoning LLM has achieved a longstanding grand challenge in AI: gold medal-level performance on the world’s most prestigious math competition—the International Math Olympiad (IMO).
offline mode for @NotionHQ coming in weeks!!
If all goes well, we are talking about weeks.
New notebook for training Arc's State model for the Virtual Cell Challenge. While not exactly what State was designed for, hopefully a helpful resource for getting started. Look forward to seeing some, um State-ful models on the leaderboard ;). colab.research.google.com/drive/1QKOtYP7…
It was awesome to get early access to Grok 4 and test it on bio and health benchmarks! Awesome work by @timjhudelmaier @adibvafa @Radii2323 @ishanjmukherjee for the epic sprint Congrats to @jimmybajimmyba @veggie_eric and team on the new model. Over 40% on HLE with 10x scaleup…
xAI gave us early access to Grok 4 - and the results are in. Grok 4 is now the leading AI model. We have run our full suite of benchmarks and Grok 4 achieves an Artificial Analysis Intelligence Index of 73, ahead of OpenAI o3 at 70, Google Gemini 2.5 Pro at 70, Anthropic Claude…
want to learn about #PerturbSeq data but not sure where to start? working on the #VirtualCellChallenge? we're pleased to share differential expression summary statistic tables from five perturb-seq atlases collected by @josephmreplogle! (link below)