Dave Burke
@davey_burke
CTO at Arc Institute | Google Advisor (Android) 🇮🇪 + 🇺🇲
Excited to announce Arc Institute's first virtual cell model: State. Reliably predicting cellular responses to drug and genetic interventions is arguably the next frontier in AI & biology. arcinstitute.org/manuscripts/St… arcinstitute.org/news/virtual-c…
New notebook for training Arc's State model for the Virtual Cell Challenge. While not exactly what State was designed for, hopefully a helpful resource for getting started. Look forward to seeing some, um State-ful models on the leaderboard ;). colab.research.google.com/drive/1QKOtYP7…
Patrick Collison says humanity has never cured a complex disease. Not cancer. Not Alzheimer’s. Not Type 1 diabetes. His Arc Institute is trying something new: Simulate biology with AI. Test interventions before touching the body. Build a virtual cell. Test hypotheses in code.…
Getting to the virtual cell is the holy grail of life science. Now there's a challenge on to accelerate it cell.com/cell/fulltext/… @arcinstitute @CellCellPress @nvidia @10xGenomics @yusufroohani @StanfordAILab @davey_burke @UltimaGenomics
We’re also excited about this result! Zero-shot prediction showed clear value of embeddings: - Pretraining State on Tahoe-100M - Fully fine-tuning on smaller, noisier datasets - Led to more accurate perturbation ranking prediction than mean baselines or HVG-trained State models
The result I'm most excited about from Arc's new State model: The ability to generalize on zero-shot out-of-distribution predictions after pre-training on the TAHOE-100M data set. Whereas PLMs have seemingly benefitted less from scaling data and model size, this is an inkling…
Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases In new @arcinstitute work, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement
What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
Arc is hiring a Chief Scientific Officer! Come work with at what I think is the most dynamic and ambitious biology research organization in the world, partnering with @pdhsu, @SKonermann, @davey_burke, Arc's extraordinary faculty, and many more. We want to build the world's…
"The next computer? Your glasses". Great job painting the vision for Android XR and showing the latest progress, @izadi_shahram! (Nice live demoing skillz by Nishtha & Max too) ted.com/talks/shahram_…
"Pico Wisdom" weekend project. Raspberry Pi Pico with e-ink display. Push button to get a wise phrase. 8 year battery life via ext switch circuit + auto power down. Prototype shown - intended as part of a picture frame. h/t @dps for Pico/e-ink inspo. Code github.com/daveyburke/Pic…
