Elmira Khabusheva

Excited to share the @Goodell_Lab News&Views on 3 exciting studies by @VassiliouLab, Chan Lab, and @TrowbridgeLab in @Nature and @NatureComms, showing that blood stem cells with mutant #DNMT3A (major driver of Clonal Hematopoiesis) depend on enhanced mitochondrial respiration ⬇️

Online Now: HIF-independent oxygen sensing via KDM6A regulates ferroptosis dlvr.it/TM5jB3

We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas. tinyurl.com/4yrwftrn

📢 For all HaloTag lovers💙💚💛❤️💜🩶 we are excited to share that our work, in which we developed a new biotin-HaloTag ligand, is now published in @JCellBiol! Full link here: rupress.org/jcb/article-ab…

Optical pooled screening is enhanced by amplification of barcodes before in situ sequencing go.nature.com/3ZVzqOi rdcu.be/exfh0

Out today in ⁦@LeukemiaJnl⁩ Our study of Erythroid-predominant MDS with distinct genotypes and associated with prognostic and therapeutic implications. #MDSsm #hemepath ⁦@GMontalbanBravo⁩ Alex Bazinet, ⁦ nature.com/articles/s4137…

ICYMI: Putting AML Differentiation States on the BoneMarrowMap brnw.ch/21wUj48 @livius_tacitus

Cisplatin and temozolomide combinatorial treatment triggers hypermutability and immune surveillance in experimental cancer models dlvr.it/TM0Npb

Delighted to share an updated review and our perspectives on clonal hematopoiesis and cancer in @NatureCancer in collaboration with Xiurong Cai and Bobby Bowman: rdcu.be/ewN62

Online now: Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections dlvr.it/TLz40Q

A special @jclinicalinvest series on #PancreaticCancer led by @BenStanger01 jci.org/articles/view/… jci.org/articles/view/… jci.org/articles/view/… jci.org/articles/view/… jci.org/articles/view/… Articles by @lauradelongwood @Muir_Lab @MaddipatiLab

Regulation of inflammatory responses by pH-dependent transcriptional condensates: Cell cell.com/cell/fulltext/…

Delighted to have our preprint led by @lvchosen1 up: Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells biorxiv.org/content/10.110… 🧵 below ...

1/ Can we control how cells sense external stimuli by modulating their epigenetic states? 🧬🧪 Our latest study shows that targeted DNA methylation editing can shape cell fate & inflammatory responses in immune cells-now out in @ScienceAdvances! 👇 science.org/doi/10.1126/sc… 🧵:

.@yadav_anoop101, Jadhav, @SvendaJakub, @HanaSedlackova1 et al. present a novel cell-permeable biotin-HaloTag ligand. The reported ligand enables in vivo labeling & provides capabilities for efficient affinity capture of protein variants from live cells. hubs.la/Q03xv9Sd0

Online now: CINTER-seq: Chemical profiling reveals interaction-dependent cell landscapes and gene signatures in vivo dlvr.it/TLy21K

🔥NEW paper from our lab! Ever wondered how the metabolite/lipid composition of human bone marrow HSCs changes during differentiation,aging,AML? Check our work nature.com/articles/s4155… driven by the brilliant @MCRomeroMulero & @Marialena_L with Jörg! @mpi_ie @ETH_en @NatureCellBio

So excited to share a pre-print of my thesis work! Check it out to see how we can leverage an epigenetic resistance mechanism to PI3K inhibitors to target leukemic stem cells!! (Spoiler alert: PRC2 is involved!) Really proud of this work conducted with @Gritsman_lab

During obesity, the bone marrow is dysregulated to overproduce myeloid cells that drive systemic inflammation. Quin Waterbury, Timothy Wang et al. @columbiacancer show that neutrophil migration is a key mediator of this process. hubs.la/Q03x3Z2b0

We’re @BlaineyLab sharing a major update to CROPseq-multi, our versatile system for CRISPR screens that is compatible with individual and combinatorial perturbations, diverse SpCas9-based technologies, and multiple high-content, single-cell readouts. biorxiv.org/content/10.110…

JAK2 inhibition mediates clonal selection of RAS pathway mutations in myeloproliferative neoplasms nature.com/articles/s4146…