Journal of Experimental Medicine

Pauken, Markson, Sharpe et al. @harvardmed show that when PD-1–expressing and PD-1 knockout CD8+ T cells are within the same tumor microenvironment, both cell types exhibit similarly enhanced functions. hubs.la/Q03yMS7M0

Great work by Riem Gawish team - excited to see our collaborative follow up published soon too!

New content is available in our journal-based #CME activities @MSKCME: 📄 “Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein” (van Dijk et al. hubs.la/Q03wy9dN0 Begin the activity 👉 hubs.la/Q03wyb6p0

At #JEMjc, we discussed a recent paper @ImmunityCP by Drs. Etienne Humblin, @KamphorstAlice and colleagues on the unexpected findings about ICOS costimulation. #TCellExhaustion #Immunotherapy #Costimulaiton cell.com/immunity/fullt… #Costimulation

A new workflow called PathMHC, developed by Leddy et al. @MIT combines computational tools with targeted mass spectrometry to help find pathogen-derived antigens presented on MHCs by infected cells that could be targets for T cell priming vaccines. hubs.la/Q03y2KbC0

Using immunoglobulin knock-in mice, Nair, Feng, Akauliya, Wilson @scrippsresearch Batista @mit et al rediversify germline & mature versions of the human anti-#SARSCoV2 spike antibody CR3022 to obtain broadened reactivity against human & bat coronaviruses hubs.la/Q03xH60S0

Congrats to my superior student #XiaoyunLi and postdoc @sofie_h_moller and all team members. It was a fun journey to work with mycollaborators in Taiwan and Paris. @Ludwig_Cancer @CancerResearch @unil

Happy to share this work, where Xiaoyun and I dissect the metabolic crosstalk between cells within the tumor microenvironment. Starring tumor cells, fibroblasts and macrophages 🎬⭐️. Check it out. With @PCHo_Lab.

JEM is pleased to present opportunities to engage in #CME @MSKCME. The latest activity is here 👉 hubs.la/Q03wHH4N0 📄 New content: “Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein” by van Dijk et al. hubs.la/Q03wHGhq0

Li, Møller, Ho et al. @unil show how tumor-derived lipids can induce an IL-6–dependent increased glutamine synthesis pathway in cancer-associated fibroblasts, supporting CAFs ability to promote pro-tumorigenic tumor-associated macrophages. hubs.la/Q03xvmfr0

Insights from Mahfoud & Padera: Geng et al. (hubs.la/Q03xjqs70) show that LEC S1P/S1PR1 signaling plays a role in mesenteric TLS formation in the absence of subclinical inflammation and, importantly, is a key regulator of lymphatic valve development. hubs.la/Q03xjqQN0

Mizuno lab @HiroshimaUnivEn show monoallelic mutations in MMD2 disturb fMLP-induced activation of Ras/ERK signaling & underlie the impairment of neutrophil chemotaxis which leads to the development of the autosomal dominant form of aggressive periodontitis hubs.la/Q03xjqVS0

Marie Ménard, @HiroyukiYoda, @WAWeissLab @UCSF and colleagues describe a Mycn-nGEMM for neuroblastoma. Murine & human neuroblastomas show profound immunosuppression mediated by PD-L1–expressing TAMs. hubs.la/Q03x48p10

During obesity, the bone marrow is dysregulated to overproduce myeloid cells that drive systemic inflammation. Quin Waterbury, Timothy Wang et al. @columbiacancer show that neutrophil migration is a key mediator of this process. hubs.la/Q03x3Z2b0

Insights by Mangalmurti and @LukensJohnR: Yang et al (hubs.la/Q03x3Y_60) provide an exhaustive study of a novel mouse model of NGLY1 deficiency, a devastating neurological disease, & implicate the cGAS-STING pathway in mediating key disease features hubs.la/Q03x3Yxx0

Thrilled to share that our latest work has been published in @JExpMed! We developed a novel Mycn-driven neuroblastoma mouse model—an innovative model to understand immunosuppressive neuroblastoma. @WAWeissLab @UCSFCancer @UCSF 1/n rupress.org/jem/article-ab…

Nan Yan lab describe an inducible Ngly1 knockout mouse model, iNgly1−/−, that reveals pronounced loss of Purkinje cells in the cerebellum w/out neuroinflammation. Sting1 knockout or STING inhibitor VS-X4 significantly rescues iNgly1−/− disease in mice. hubs.la/Q03x3QwQ0

A leap for cancer immunotherapy! Prof. Fu Yangxin & Liang Yong from the School of Basic Medical Sciences co-developed a membrane-bound IL-12 mRNA-LNP vaccine. Published in @JExpMed, it boosts tumor-specific T cell responses while minimizing side effects. bitly.cx/f2ny

Interested in how obesity influences autoimmunity in the context of arthritis? Please check out our paper which implicates IFN type 1 signaling in T cells. Much thanks to #ANRF for funding this project!

This #JEMLegacy tweet takes you to a 1999 study by Dr. Muriel Moser that demonstrated the functional dichotomy between CD8a+ and CD8a- DCs in driving distinct T helper cell responses. rupress.org/jem/article/18… #Immunology #DendriticCell #THelperCell