The Lewis Lab

@PeterLewisLab

Chromatin biochemistry and genomics in development and cancer. @UWMadison @UWSMPH @BMC_UW

Wisconsin, USA

Joined March 2019

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The Lewis Lab@PeterLewisLab · Jul 23

We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas. tinyurl.com/4yrwftrn

PeterLewisLab's tweet image. We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
tinyurl.com/4yrwftrn

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Jeannie Lee@XistHarvard · Jul 24

An evolving landscape of PRC2–RNA interactions in chromatin regulation, by Aguilar @ragmau, Rosenberg, et al. now in print! Learn the latest about how Polycomb works with RNA in epigenetic regulation: nature.com/articles/s4158…

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Epigenome Technologies Inc.@EpigenomeTech · Jul 22

Epigenetics Update - Structural mechanism of H3K27 demethylation and crosstalk with heterochromatin markers bit.ly/44H3zCZ Robert K. McGinty (UNC) reproting in Mol Cell #Epigenetics #DNADemethylation #Chromatin --- Discover the breakthrough at epigenometech.com

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ShorterLab@ShorterLab · Jul 24

G-quadruplexes are promoter elements controlling nucleosome exclusion and RNA polymerase II pausing: nature.com/articles/s4158…

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The Lewis Lab@PeterLewisLab · Jul 23

Domain analysis identifies a discrete nucleic acid-binding domain (NBD) within SUZ12 responsible for constraining PRC2 activity. CryoEM studies showed the NBD in close proximity to nucleic acids. Loss of this region (NEC, VEFS) causes global H3K27me3 hypermethylation. 11/13

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The Lewis Lab@PeterLewisLab · May 21

Check out this 🧵from @EimearLagan on our new @MolecularCell paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇

EEimear Lagan@EimearLagan · May 21

Excited to share our new paper out today in @MolecularCell! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).

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Chen Davidovich@DavidovichLab · Mar 15

1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance? We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains. 🧵 biorxiv.org/content/10.110…

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The Lewis Lab@PeterLewisLab · Jun 16

It was a privilege to be part of the Allis lab. Dave fostered an environment of rigor, curiosity, and kindness- his impact lives on in the many he mentored. Grateful to reconnect at Rockefeller with this extraordinary group. Thank you to the organizers for an inspiring symposium.

PeterLewisLab's tweet image. It was a privilege to be part of the Allis lab. Dave fostered an environment of rigor, curiosity, and kindness- his impact lives on in the many he mentored. Grateful to reconnect at Rockefeller with this extraordinary group. Thank you to the organizers for an inspiring symposium.

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