Felix Horns
@FelixHorns
Core Investigator at Arc Institute | Assistant Professor at Stanford | Synthetic biology, genomics, human health
We're hiring! Our group @arcinstitute and @Stanford has postdoc openings in 1) discovering and developing next-generation therapeutic delivery vehicles, and 2) tracking cellular dynamics. Email me if you're interested! hornslab.org
Our work with the STATE model tackled context generalization for *seen* perturbations. @arcinstitute's Virtual Cell Challenge (VCC) focuses on a more challenging scenario: context generalization for *unseen* perturbations. Colab notebook to train your own STATE models for VCC:…
Register today for the Virtual Cell Challenge and use AI to solve one of biology’s most complex problems. Announced in @CellCellPress, the competition is hosted by Arc Institute and sponsored by @nvidia, @10xGenomics, and @UltimaGenomics.
In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput method to measure nuclear condensate formation & applied it to ~14000 IDPs to find out rdcu.be/eq975
Cool! What a tour de force. Congrats @LukeKoblan and team!
1/14 On behalf of the amazing team in @JswLab, we’re excited to share PEtracer (biorxiv.org/content/10.110…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse…
Neat use of single nucleus RNA sequencing in plants to identify biosynthetic pathways
Today in @Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III and dBz-deoxy-Taxol. a…
🚨 New preprint 🚨 of our new #ML dimensionality reduction method (DR-GEM). Singular/unique things can be right in front of us, but we still won't see them. We show why this happens to unsupervised learners and how to make these learners "see" by self-supervising themselves.…
How can one efficiently simulate phylodynamics for populations with billions of individuals, as is typical in many applications, e.g., viral evolution and cancer genomics? In this work with @mcelentano, W. DeWitt, & S. Prillo, we provide a solution. doi.org/10.1073/pnas.2… 1/n
Arc is hiring a Chief Scientific Officer! Come work with at what I think is the most dynamic and ambitious biology research organization in the world, partnering with @pdhsu, @SKonermann, @davey_burke, Arc's extraordinary faculty, and many more. We want to build the world's…
We're hiring a CSO to lead our institute initiatives!
Arc is hiring a Chief Scientific Officer! Come work with at what I think is the most dynamic and ambitious biology research organization in the world, partnering with @pdhsu, @SKonermann, @davey_burke, Arc's extraordinary faculty, and many more. We want to build the world's…
This opens new frontiers in genome design, awesome work, congratulations @ntperry13 @pdhsu and team!
Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases In new @arcinstitute work, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement
Great opportunity!
We are looking for a research assistant to join the lab and work on spatial genomics. Please help spread the word—thanks! careersearch.stanford.edu/jobs/life-scie…
Want to discover, design, and engineer cutting-edge drug delivery vectors? We're hiring a PhD-level Scientist at the Horns Lab at @arcinstitute and @Stanford! Check out bit.ly/ScientistDeliv…
It's been a pleasure having @alishbaimran_ on our team as a Research Fellow! Her passion and drive made a real impact! We're always eager to collaborate with curious, motivated students—especially those excited about AI for biological discovery. Don't hesitate to reach out!
Thrilled to have joined @nabilwrites on his podcast, Discovery Engines! We talked about breaking into AI for Science, and my current work in ML for modeling cells. Check out the episode below - links in thread!
1/ 🧵 THREAD: Here’s how we solved a 30-year mystery about an HIV drug. 💊 A drug used for over two decades ⚠️ Pulled from the market for cardiac risk 🤯 And no one knew why — until now We found the missing mechanism using our single-cell mosaic dataset, Tahoe-100M. Let’s talk…
🚨Preprint alert!🚨 Why do high-altitude populations have lower rates of metabolic syndrome and lower blood glucose? Superstar postdoc Yolanda tackled this❓tinyurl.com/2x7ptyn8 @GladstoneInst @arcinstitute @UCSF #hypoxia #oxygen
Today, we're announcing new partnerships with @10xGenomics and @UltimaGenomics to accelerate development of the Arc Virtual Cell Atlas. (1/6)
Bringing sequencing data formats into the modern age, great to see this out @noamteyssier
I'm excited to release what I've been cooking up the past few months at @arcinstitute BINSEQ is a family of binary file formats for sequencing data built with paired records and parallel processing in mind with big performance gains (2x-40x) over gzip-fastq with similar storage
Check out this beautiful work on the next generation of spatial omics! Congrats @yodai_takei @LongCai_Lab and colleagues
Excited to share our new paper out in @Nature revealing cell-type specific nuclear organization and its link to gene regulation using new spatial multi-omics technologies! nature.com/articles/s4158…
We are glad to present our exploration of aging, dietary restriction, genetics, and the microbiome, led by @levlitichev, together with our collaborators @jacksonlab and @calico, just published at @NatureMicrobiol. Major findings are the following: (1/8) nature.com/articles/s4156…