Luke Koblan
@LukeKoblan
HHW fellow at @WhiteheadInst in @JswLab | Chemical Biology PhD @Harvard in @liugroup | Genome editor by day, also a genome editor by night
TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules
An article in today’s @nytimes provides a small glimpse at the incredible progeria community. The hard work, dedication, and energy of the amazing patients and the thoughtful scientific leaders have made all of the progress in this field possible. It is such an honor to be a…
A recount and update on our efforts to bring base editing to progeria patients as part of a team including Francis Collins, @SammyBasso, Mike Erdos, Leslie Gordon, @Progeria @LukeKoblan, Meirui An, @danielxingao, and others, beautifully told by @ginakolata in the @nytimes:…
Awesome stories out from @brian_b_liau and his fantastic team!
Excited to share 2 preprints, together showing how mechanisms of a molecular glue & E3 ligase cancer mutations serendipitously converge to cause neomorphic protein degradation in distinct contexts. Highlights below: 1/17 #1: biorxiv.org/content/10.110… #2: biorxiv.org/content/10.110…