Kalli Kappel
@KalliKappel
HHMI Hanna Gray Fellow & @SchmidtFellows @broadinstitute | Soon: Asst Prof @UCLA | PhD: @Stanford Biophysics @RDasLab | RNA+proteins+IDPs, HT expts+computation
In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput method to measure nuclear condensate formation & applied it to ~14000 IDPs to find out rdcu.be/eq975
Beautiful work led by the brilliant @GraceKC! Check it out!
Can we use RNA to insert kilobases of DNA into the human genome, opening up a new way to engineer cells or treat disease? Excited to share our latest work turning a retrotransposon (a “jumping gene” with an RNA intermediate) from songbirds into a genome editing tool. 🧵 (1/7)
Excited that our paper describing accelerated 3D RNA structure determination is out @naturemethods! This was an amazing collaborative effort with @chiulab, especially @kaiming_zhang and Zhaoming Su, and many wonderful @RDasLab members: nature.com/articles/s4159…
Ribosolve accelerates RNA 3D structure determination with cryo-EM, multidimensional chemical mapping, and Rosetta modeling. @KalliKappel's paper on Ribosolve is now at @naturemethods, with 11 sub-nanometer resolution structures for protein-free RNA: nature.com/articles/s4159…
Introducing CondenSeq, an imaging-based high-throughput approach for characterizing protein condensates within the nuclear environment. @KalliKappel nature.com/articles/s4159…
This is so cool! Congratulations Dan!!
Excited to share DIRECTED (Delivery to Intended REcipient Cells Through Envelope Design): a programmable platform for cell-type-specific delivery. rb.gy/c3rdw Thank you to @FrangiehChris, @mircoscopy, @GuilhemFaure, Rhiannon Macrae, @zhangf 1/7
Excited to share this work! nature.com/articles/s4158…
We’re excited to report today in @nature the cryo-EM structure of the OMEGA family member IsrB in complex with ωRNA and target DNA. nature.com/articles/s4158…
Out now in @Nature: 🧬 Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA. By Seiichi Hirano, Kalli Kappel, Feng Zhang & colleagues. @KalliKappel @zhangf nature.com/articles/s4158…
Our high resolution cryo-EM structures of the Tetrahymena ribozyme are out @nature! Congrats @SuZhaoming @kaiming_zhang @RDasLab @chiulab! nature.com/articles/s4158…
Honored and grateful to be selected as one of the new HHMI Hanna Gray Fellows! Huge thanks to my mentors Aviv Regev, @zhangf, and @RDasLab and all my wonderful colleagues at the @broadinstitute!
Today, HHMI is proud to announce the new #HannaGrayFellows, 21 early career researchers who are taking on some of the biggest challenges in the life sciences. bit.ly/3atgdcz