Dong-Jiunn Jeffery Truong
@Earthnut89
Just some Dude. Don't take me seriously. I'm living from Memes & Science & 🥟.
Give MAP-MS a try on your Orbitrap- no hardware or software changes needed! Curious how it works? Check out @briansearle tweet for the details. #MassSpec #Orbitrap #asms2025 Huge thanks to coauthors and everyone who supported us during this work!
People have asked about how MAP-MS works so here's a tweetorial on @teerap16's new preprint: biorxiv.org/content/10.110…. MAP-MS takes advantage of parallelization in a trapping MS, collecting Orbitrap MS1s with 2x the dynamic range by differentially amplifying parts of the ion beam.
New pre-print(s) from the Sternberg Lab in collaboration with @LeifuChangLab! We uncover an unprecedented molecular mechanism of CRISPR-Cas12f-like proteins, which drive RNA-guided transcription independently of canonical promoter motifs. Full story here: tinyurl.com/mr3fd493
The peer-reviewed version of expansion in situ genome sequencing is now out in Science! The news is bittersweet – when we first revealed this last September, I never guessed it would be my final paper in academia, but a lot has changed. A few parting thoughts:
1/10 Today in @ScienceMagazine in collaboration with @liugroup we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-UbCR…
ENVLPE packaging constructs are now available for ordering on @Addgene, including the most important pegRNAs, nsgRNAs and sgRNAs used in the study. addgene.org/browse/article…
doi.org/10.1016/j.cell… ENVLPE, our system for VLP-based delivery of gene editors, is now published in @CellCellPress. We showed efficient delivery of base- and prime-editors in primary T cells & in vivo retinal models. Congrats co-first-authors @geilinho & @niggles293T!
Engineering Smart Delivery for Gene Editors 🧬 👉t1p.de/vmdc9 A research team from #HelmholtzMunich and @TU_Muenchen has developed an advanced delivery system that transports gene editing tools based on the CRISPR/Cas9 gene-editing system into living cells with…
doi.org/10.1016/j.cell… ENVLPE, our system for VLP-based delivery of gene editors, is now published in @CellCellPress. We showed efficient delivery of base- and prime-editors in primary T cells & in vivo retinal models. Congrats co-first-authors @geilinho & @niggles293T!
Last night I was honored to receive the 2025 #BreakthroughPrize in the Life Sciences, reflecting the efforts of many students, collaborators, doctors, and patients in labs around the world. I hope this 4-minute excerpt can inspire when science needs public support more than ever.
We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their…
Nature research paper: RNA control of reverse transcription in a diversity-generating retroelement nature.com/articles/s4158…
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”. doi.org/10.1038/s42255… A tremendous collaborative effort led by @JohannaSiehler, @BilekovaSara and other members of the @LickertHeiko lab.
Check out our new preprint! arxiv.org/abs/2410.02543 We find that Diffusion Models are Evolutionary Algorithms! By viewing evolution as denoising, we show they share the same mathematical foundation. We then propose Diffusion Evolution (1/n)
Evidence of artefactual calcium microwaves during calcium imaging of neurons in the hippocampus. elifesciences.org/articles/93804…
TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules