David R. Liu
@davidrliu
Professor at Harvard, Broad Institute, & HHMI. Our lab integrates chemistry & evolution to illuminate biology & enable new therapeutics. IG/Threads: @davidrliu1
Today in @CellCellPress we report the use of prime editing to correct several mutations that cause alternating hemiplegia of childhood (AHC), a rare and devastating neurodevelopmental disorder, in patient-derived cells and in two mouse models. drive.google.com/file/d/1ibC50t… 1/10
Brilliant collab of @davidrliu (@broadinstitute / @Harvard) & Cat Lutz (@jacksonlab) shows that durable in vivo primed editing of a neurodevelopmental disorder proves the feasibility of creating bespoke gene-editing drugs for a single disease in parallel. insideprecisionmedicine.com/topics/transla…
One-shot prime genome editing ("CRISPR 3.0") of the brain in vivo corrected AHC, a rare genetic disorder, in the mouse model. Another big step forward in the genome editing field. @CellCellPress @davidrliu and colleagues cell.com/cell/fulltext/…
Just published: nature.com/articles/s4158… Coenzyme Q10 (CoQ10) is critical for mitochondrial function and for controlling reactive oxygen species damage to biological membranes. Because CoQ10 is poorly bioavailable, new approaches are needed to promote CoQ10 synthesis. In our…
💬 "L’humanité pourra bientôt agir sur son destin génétique" Le scientifique américain @davidrliu (@Harvard) a révolutionné les technologies d’édition du génome. En réécrivant l’ADN, ses "machines moléculaires" sauvent déjà des vies. 🧵 1/6 👇 l.lexpress.fr/tkQ
The Gene Editor: 2025 Breakthrough Prize winner David Liu introduces base editing and prime editing, the transformative technologies that could repair almost any genetic mutation.
Gene editing pioneer @davidrliu discusses baby K.J. Muldoon, the first person treated with a customized gene editing therapy, what made K.J.'s treatment possible, and how on-demand treatments for rare genetic diseases could one day become routine. broad.io/DLQA
A preprint from @nataliyakosmyna and coworkers reports EEG evidence that writing using LLMs reduces neural connectivity and cognitive engagement compared to unaided writing or using standard search engines. Persistent use of LLMs weakened cognitive activation and impaired memory…
1/14 On behalf of the amazing team in @JswLab, we’re excited to share PEtracer (biorxiv.org/content/10.110…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse…
.@SecKennedy - thank you so much for your broad support for gene editing and gene therapies as well as recognizing the importance of Baby KJ’s story and the potential that CRISPR base editing therapies hold for patients with severe genetic diseases. I’m thrilled you have publicly…
Thursday morning, I had the privilege of speaking with the Muldoon family, whose 10-month-old son, baby KJ, was discharged Wednesday from @ChildrensPhila. Baby KJ was diagnosed with a rare urea cycle disorder and received a first-of-its-kind personalized CRISPR gene-editing…
LIVE NOW: FDA's Cell and Gene Therapy Roundtable Captions available here: bit.ly/4dQaNaz