zack chiang
@z_chiang
microscopy x omics
What do you do when grants are cancelled, faculty searches are frozen, and the ability to do the science you believe in is slipping out of reach? I wrote an essay. On efforts to solve aging with reprogramming, the primacy of the epigenome, and the path to rewriting our future:
The first pivotal, FDA-enabling clinical trial of a longevity drug is now fully enrolled We will monitor these dogs for the next ~4 years, quantifying millions of data points across biological changes, quality of life, disease, + lifespan
1,300+ dogs. 72 clinics. One giant leap toward the first FDA-approved lifespan extension drug for dogs. The STAY study is fully enrolled!
tfw your question gets asked on the @dwarkesh_sp @geochurch podcast 🥹
Why has the fall in DNA sequencing costs had so few tangible benefits despite outpacing Moore's law?
really enjoyed this essay, it captures a lot of the issues that broadly plague science and puts them in simple terms these issues are only amplified in biology where the timescales are far longer and the rewards less evenly distributed
## The case for more ambition i wrote about how AI researchers should ask bigger and simpler questions, and publish fewer papers:
can someone please train a deep learning weather model to explain why it rains every freakin' weekend in boston
Super excited that Expansion In Situ Genome Sequencing (ExIGS) is out now in @ScienceMagazine ! Check out the paper to see what can be revealed by sequencing the genome in its native position and high-res imaging its interactions with nearby proteins. science.org/doi/10.1126/sc…
A new combination technique enables DNA sequencing and high-resolution imaging in intact cells — offering new insights into progeria and aging. broad.io/expansion-in-s… @JD_Buenrostro @insitubiology @ajaylabade31 @CarolineComenho @z_chiang @ScienceMagazine
Thrilled to announce that our work on Expansion In Situ Genome Sequencing (ExIGS) is now published in @ScienceMagazine! ExIGS allows us to sequence DNA and image proteins with super-resolution directly within single cells. science.org/doi/10.1126/sc…