William Gibson
@wgibson
MD, PhD | Gibson Lab @DanaFarber | Broad Institute | Genomics+Chemical Biology
The first time I saw "metformin effect" on a PET/CT for one of my patients, I was bowled over; it is not subtle. Now some quantification of how metformin causes the gut to excrete glucose, maybe a hint at its mechanism of action. ***How does a molecule like that achieve this!?
More quantification of intestinal glucose flux in mice and humans with and without metformin @CommsBio nature.com/articles/s4385…
tfw you put out a postdoc ad
The only thing that matters about this famous classified ad is the last line. Neglect these things and the whole agreement falls apart
I've really enjoyed working with Will the past few years and would highly recommend his lab to anyone interested in chem bio/cancer bio
Happy to announce my next career step - I’ve launched my independent research lab at Dana Farber! If you are a trainee interested in ambitious projects at the intersection of chemical biology and cancer biology, please reach out! gibsonlab.org
Fascinating work showing that the covalent addition of a nuclear importing compound, JQ1, to therapeutic oligonucleotides enhances their activities by enhancing nuclear penetration.
We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer! Preprint led by @disha_kashyap_ @milnetom68 @chem_in_cells @OxfordChemistry @UCLChemistry chemrxiv.org/engage/chemrxi…
This first-in-class CCNE1 degrader from Monte Rosa is really impressive. It's a molecular glue that finds a shallow pocket on CCNE1 and displays cooperative binding to CRBN, w/ EC50 of 3 nM for the ternary complex. Highly specific CCNE1 degradation. ir.monterosatx.com/static-files/d…
Always dreamed of being in drug hunter!
July 2024 Molecule Roundup In this article, you'll find a curated selection of nearly 50 molecules from July that piqued our interest, highlights of some of our favorites, and explanations of why they're worth watching. Article Link | drughunters.com/4dZvWhp
Hallmark of oncogenic mutant p53? Exceptionally high levels of expression. How to exploit for treating cancers? A bifunctional Chemical Inducer of Proximity (CIP) that targets a cytotoxic small molecule to mutant p53 cancers. See thread by @wgibson
TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules
@wgibson and I develop the first generalizable strategy to drug the most mutated gene in cancer: TP53
TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules