Arpiar Saunders, PhD
@your_arpy
Neurophysiologist & molecular engineer at @OHSUBrain. Developing viral tech to map the brain’s cellular organization and understand neuropsychiatric disorders.
@kennypavan's AnnSQL software for facile, lightning-fast analysis of large-scale scRNA-seq datasets is out now in @BioinfoAdv. >19k downloads thus far and we'd love to grow the developer base. Easily analyze millions of RNA profiles from your laptop. No HPC necessary!
🔍 Recently published in Bioinformatics Advances: "AnnSQL: A Python SQL-based package for fast large-scale single-cell genomics analysis using minimal computational resources" Read the full paper here: doi.org/10.1093/bioadv… Authors: @kennypavan and @your_arpy
An @OHSUNews lab is working on a universal flu vaccine that could, in theory, protect people from the virus for life. #Research on nonhuman primates is critical for being able to replicate how complex systems respond to new therapies. oregonlive.com/opinion/2025/0…
Why do we go downstairs when we hear a scary noise at night? Postdoc Kati Rothenhoefer shows how novelty seeking & explore-exploit decision making in #macaques resolves curiosity about whether choices will lead to appetitive or aversive outcomes. biorxiv.org/content/10.110…
I wrote an Op-Ed about the government's attacks on Harvard. Please share with anybody who thinks these attacks help anybody. prosyn.org/PhWi74r?h=KyJ1…
Well-deserved @SynBioGaoLab !
Grateful for the recognition and for my team's dedication. When I wrote it in Oct, I didn't anticipate that the title would feel defiant. The original draft even had a now quaint reference to "the comparative comfort of the ivory tower", which was wisely removed.
Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🐁 Led by Ling-Xiao Shao and @ItsClaraLiao Funded by @NIH @NIMHgov 📄Read in @Nature - nature.com/articles/s4158… 1/12
Hey there science friends! Has your funding been cut or do you know someone whose funding has been cut? I’m starting a podcast to highlight your research in particular! If you’re interested in being featured, reach out by DM or email!
Are we living in the twilight zone?
Last night my brilliant friend with 20 years of expertise in Neuroscience including a decade at NIDA was fired because she was recently promoted for her outstanding performance and it triggered the probation period. This is not making NIH more efficient, this is not making us…
The pointless destruction of the scientific and medical research system open.substack.com/pub/stevensalz…
Despite the trying times, thrilled to share our @NatureProtocols piece on massively parallel in vivo Perturb-seq: nature.com/articles/s4159…
It’s important for us scientists to articulate that the NIH cuts are surgically cruel: designed not to save money, but to maximally implode the capacity and infrastructure for research; research that saves and improves lives around the world. Why? Just cruelty.
NIH grants drive more than $92.89 billion in economic activity across all 50 U.S. states and DC. It is estimated that every dollar of NIH funding generates $2.46 dollars of economic activity. So what you are bragging about is a more than $22 B hit to local economies across the US
Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above…
if this holds, this will cripple US science, with ramifications that cant be easily reversed
Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above…
🧠 Curious about neuromodulator interactions or how sleep works its magic? Apply to our lab @WashUMedNeuro as a postdoc to bridge cellular & systems neuroscience by decoding biochemical signaling dynamics in the brain! Please RT. #Neuroscience #PostdocOpportunity #BrainResearch
🚨Job Alert 🚨 Postdoctoral Research Associate (Chen Lab) @yaochen20’s interdisciplinary lab in the Department of Neuroscience at WashU Medicine seeks a motivated postdoctoral researcher to join the team. Learn more and apply: neuroscience.wustl.edu/items/postdoct…
Excited to share the paper: Huntington's disease is a DNA process for almost all of a cell's life. Inherited HD alleles are innocuous, just unstable – CAG repeats slowy expand throughout life. We call it a "ticking DNA clock". cell.com/cell/fulltext/…
Appreciate this generous write up on our recent preprint! thetransmitter.org/spectrum/hair-…
John Tuthill @casa_tuthill explains why practical summer courses in neuroscience matter and how this tradition helps researchers rekindle the unfettered joy that initially brought them to the field. thetransmitter.org/craft-and-care…
Now published @NAR_Open! SspA is a transcriptional regulator of CRISPR adaptation in E. coli. academic.oup.com/nar/advance-ar…
New preprint from the lab, on the fundamental biology of CRISPR adaptation! Check out the preprint here: biorxiv.org/content/10.110… Or, start with this wonderful highlight thread by @oso_de_antojos who led the work. @GladstoneInst @UCSF @UCSF_BTS @BioE_Beast
Our latest work in collaboration with the Bourhy Lab (Pasteur Inst.) in which we use scRNA-seq to characterize host-rabies molecular interactions across diverse human brain cell types. Recommended if you're interested in "system virology" or glial biology: tinyurl.com/3a7e9vwp
Today we introduce a new drug candidate for prion disease: a PrP-lowering divalent siRNA. A 4-year collaboration with @RTI_UMassChan enabled by @NINDSfunding IGNITE & URGenT mechanisms. biorxiv.org/content/10.110… Our hope is to advance this to the clinic, wish us luck!