Seth Shipman
@seth_shipman
scientist. shipman lab at gladstone | UCSF.
The June issue is live nature.com/nbt/volumes/43… On the cover, Khan et al. present a molecular census of retrons, performing the same battery of tests across many distinct systems to identify similarities and differences go.nature.com/3MOsMBx
Now published @NAR_Open! SspA is a transcriptional regulator of CRISPR adaptation in E. coli. academic.oup.com/nar/advance-ar…
New preprint from the lab, on the fundamental biology of CRISPR adaptation! Check out the preprint here: biorxiv.org/content/10.110… Or, start with this wonderful highlight thread by @oso_de_antojos who led the work. @GladstoneInst @UCSF @UCSF_BTS @BioE_Beast
🚨 Episode 6 of #FromBenchtoPodcast is live! 🎙️👩🏻🔬 Tune in as @ChloeFishman and I dive into the fascinating world of #PhageTherapy, the importance of #Mentorship, and a touch of #Astrobiology! 🦠👩🏻🚀 Don’t miss this exciting conversation @NatureBiotech open.spotify.com/episode/64hd7U…
Gladstone scientists undertake a major effort to examine the diversity of retrons, bacterial defense systems that can be leveraged for precise gene editing. @seth_shipman @Asim_g_Khan @matromont @alex_gonzadel @NatureBiotech @UCSF @UCSF_BTS @czbiohub bit.ly/3XIMoxb
An experimental census of retrons for DNA production and genome editing go.nature.com/3MOsMBx
Published today in @Nature, we describe an approach for single-molecule protein reading on @nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s4158…
A new retron-based method from the innovative @seth_shipman lab now allows making multiple mutations in a phage genome in a single, easy process - from point mutations to small insertions and deletions Read the overview by @IlyaOsterman nature.com/articles/s4158…
Multiplexed editing of phage genomes using retrons, now published at @NatureBiotech with lots of new bells and whistles. @ChloeFishman @katecrawdaddy @BhattaraiKline @Darshini_Poola @thekarenzhang @alex_gonzadel @matromont nature.com/articles/s4158…