Tristram Ryan

Are you interested in #immunometabolism but not sure where to start? Introducing our new book “Metabolites as Signals in Immunity and Inflammation”, co-edited with Zbigniew Zasłona (@molecure_sa) and @laoneill111 (@tcddublin), available now. shop.elsevier.com/books/metaboli… (1/n)

Beyond excited to share our #NewPaper in @CellCellPress! Inflamed environments acidify intracellular pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of inflammation. #inflammation #pH authors.elsevier.com/sd/article/S00…

#EpigeneticPower! Our #NewPaper @ImmunityCP shows that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2, blocking #IL10! authors.elsevier.com/a/1lS0g3qNrU-i…

💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. nature.com/articles/s4158… #OpenAccess at @Nature @CNIC_CARDIO #microbiome #CVD

Methylglyoxal is an antibacterial effector produced by macrophages during infection #immunometabolism cell.com/cell-host-micr…

Integrated analysis of transcriptional and metabolic responses to mitochondrial stress #mitochondria sciencedirect.com/science/articl…

#TheMoreTheMerrier! @KPekayvaz Nicolai, Stark &co show @ImmunityCP that non-classical monocytes help to resolve thrombi by recruiting neutrophils that become thrombolytic following hypoxia-induced programs! cell.com/immunity/fullt…

#EpigeneticPower! @ivashkivlab Mishra &co show @NatImmunol that anti-inflammatory IL-10 epigenetically silence IRF1 & IRF5 gene transcription by decreasing H3K27ac & chromatin accessibility, thus preventing sustained #interferons & IL6/TNF signaling! nature.com/articles/s4159…

Factor XII drives thrombosis but is dispensable for hemostasis, making it an anticoagulant drug target. We show that factor XII–triggered coagulation traps pathogens and limits bacterial dissemination, highlighting a role of prothrombotic mechanisms in innate immunity.

Not sure how useful this site is for recruitment these days, but we are looking to recruit a new postdoc asap to a funded position in our lab in Dublin. Please check out our lab website, prestonlab.ie and get in touch if interested.

Trained immunity imprints memory to subsequent infections, but it comes with the caveat of lowering the threshold for blood clots 🩸 by upregulating procoagulant tissue factor. Congrats to @AislingRehill, @rogerjspreston, and co on this important discovery. @ScienceAdvances

#EveryCellIsAnImmuneCell! @JieYang437 @RoychoudhuriLab &co show @Nature that platelet-derived thromboxane A2 suppresses T cell functions favoring melanoma metastases! Aspirin or COX1 inhibition or deletion in platelets reduce metastases! #ScienceMatters doi.org/10.1038/s41586…

Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses #immunometabolism nature.com/articles/s4158…

New publication from our group in @NatureComms led by Gemma Leon @PrestonLab_RCSI @IrishCtrVascBio Thanks to our collaborators at @tcddublin @CHIatCrumlin and to @Researchirel @CHIatCrumlin for funding. Open access link: rdcu.be/d93ds

#JoinUs! Today 4pm, Modell Center, I’ll be giving the @harvardmed @Harvard #Immunology seminar, tons of unpublished data, all about how we sense & respond to microbial & host-derived inflammatory signals during infections & sterile inflammatory diseases!

🚀 TL;DR: pip install kinase-library 🚀 We are excited to introduce #TheKinaseLibrary Python package! 🧵👇 @KinaseLibrary Jared_Johnson @Tomer_M_Yaron @CellSignal pypi.org/project/kinase…