Ivan Zanoni
@Lo_Zanzi
Associate Professor at Harvard Medical School, in love with a red-haired beautiful woman, his kids... and immunology. He/him/his. 🇮🇹 🇺🇸 Views my own.
#InterferonPower #NoTimeToDie! Kishimoto &co identify @PNASNews a STAT1 phosphorylation site that boosts integrin b4 in intestinal epithelial cells & prevents its downmodulation by IFNs, thus mitigating IFN cytotoxic functions, preserving barrier integrity doi.org/10.1073/pnas.2…
Thanks @KR_Foundation for the opportunity to share some of our data on gut repair during #IBD and for a fantastic Symposium that fostered new ideas and collaborations!
Dr. Ivan Zanoni (@Lo_Zanzi) of @harvardmed is showcasing research on molecular and cellular regulation of intestinal inflammation. #InnovationsSymposium2025
#WeekendRead! #NoTimeToDie! #InterferonPower! Wang &co show @MolecularCell that MLKL not only drives #necroptosis but also directly triggers IFNb production by releasing mitochondrial DNA & activating cGAS-#STING, which exacerbates #colitis! cell.com/molecular-cell…
Beyond excited to share our #NewPaper in @CellCellPress! Inflamed environments acidify intracellular pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of inflammation. #inflammation #pH authors.elsevier.com/sd/article/S00…
🔥🔥🔥Endogenous oxidized lipids regulate polycomb complex to epigenetically control IL10 level! Congrats to @Lo_Zanzi and Marco! What an amazing discovery👏 honored to play a tiny part in this story 👇authors.elsevier.com/c/1lS0g3qNrU-i…
#EpigeneticPower! Our #NewPaper @ImmunityCP shows that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2, blocking #IL10! authors.elsevier.com/a/1lS0g3qNrU-i…
#ChromatinPower #WhatADay! After our paper @ImmunityCP (free👉 authors.elsevier.com/a/1lS0g3qNrU-i…) happy for our tiny contribution to @XuZhouLab @RMedzhitov @younggouu &co amazing paper @CellCellPress showing pH controls inflammation via chromatin remodeling! Free👉 authors.elsevier.com/sd/article/S00…
Thanks for sharing @LabWaggoner 😌!!
Host-derived oxidized phospholipids accumulate upon microbial encounter, epigenetically suppress IL-10, and exacerbate harmful inflammation @ImmunityCP @Lo_Zanzi cell.com/immunity/fullt…
Thanks for sharing our work Jon!! 🤗
A new function for an ancient innate immune stimulus. Zanoni et al report that oxidized lipids control IL-10 expression, impacting host defense and disease. Kudos to the authors on this important discovery sciencedirect.com/science/articl…
Online now: Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections dlvr.it/TLz40Q
#MicrobiotaPower, #FriendOrFoe? @SanchoLab Mastrangelo &co show @Nature that a microbiota-derived metabolite drives #atherosclerosis in athero-prone mice in the absence of high fat diet or high cholesterol by acting directly on myeloid cells! nature.com/articles/s4158…
#WeekendRead #InterferonsFriendsOrFoes?! @RuthFranklinLab @RMedzhitov &co show @ScienceMagazine that macrophage-derived oncostatin M overcomes type I IFN detrimental effects during influenza lung infections by driving AT-II epithelial cell proliferation! science.org/doi/10.1126/sc…
Check out our paper @madisonstrine @KStDenis_ME @YalePediatrics @YaleIBIO
Exploring mucosal immune development and function in utero dlvr.it/TLrRcC
Are you interested in #immunometabolism but not sure where to start? Introducing our new book “Metabolites as Signals in Immunity and Inflammation”, co-edited with Zbigniew Zasłona (@molecure_sa) and @laoneill111 (@tcddublin), available now. shop.elsevier.com/books/metaboli… (1/n)
#MicrobiotaPower & #Exercise! Phelps, Meisel &co show @CellCellPress that exercise drives formate from microbiota that in turns activates NRF2 in CD8 T cells driving STAT1/IRF8 programs that potentiate immune checkpoint inhibitor efficacy against melanoma dlvr.it/TLqLW7
1/11 New #MRSA #Staph publication from Dr. Diane Boff a talented former postdoc co-mentored by the @TorresVJ_Lab and @DrShrutiNaik! science.org/doi/10.1126/sc…
Such a please to work with Dr. Diane Boff and @TorresVJ_Lab on this important study establishing mechanism of immune evasion in a rodent adapted strain of S aureus! #speciesmattter. Stay tuned for more stories emerging from our work together!!
1/11 New #MRSA #Staph publication from Dr. Diane Boff a talented former postdoc co-mentored by the @TorresVJ_Lab and @DrShrutiNaik! science.org/doi/10.1126/sc…
Ten days until the Letter of Intent deadline for the Burroughs Wellcome Fund's Investigators in the Pathogenesis of Infectious Disease $500,000 for assistant professors for work focused on the pathogenesis of infectious disease. Don't talk yourself out of applying!